Abstract
In a child who probably received an overdose of sodium valproate, progressive coma, intermittent tonic-clonic seizures and anuria developed. Laboratory investigations revealed coagulopathy, anaemia and mildly disturbed liver function. Progressive renal insufficiency, probably due to rhabdomyolysis and myoglobulinuria, occurred later. Treatment consisted of supportive measures, combined haemoperfusion and haemodialysis and IV thiopentone. Clinical and biochemical normalisation was observed after 11 days.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- VPA:
-
sodium valproate
References
Aguilera L, Calvo R, Garcia RC (1986) Interaction between thiopentone and sodium valproate. Br J Anaesth 58:1380–1383
Boillot A, Bourgeois F, Barale F, Lenys R, Daoudal P, Delacour JL (1981) Atteinte médullaire mortelle au cours d'une intoxication aiguë volontaire par dipropylacétate de sodium. Nouv Presse Méd 10:2038
Chadwick DW, Cumming WJK, Livingstone I, Cartlidge NEF (1979) Acute intoxication with sodium valproate. Ann Neurol 6:552–553
Cohen JJ, Harrington JT, Kassirer JP, Madias NE, Zusman CJ, Garella S (1988) Extracorporeal techniques in the treatment of exogenous intoxications. Kidney Int 33:735–754
De Broe ME, Verpooten GA (1982) Combined hemoperfusionhemodialysis in severe poisoning: a four years experience. In: Piskin E, Chang TN (eds) The past, present and future of artificial organs. Meteksan, Ankara, pp 181–195
Eeg-Olofsson E, Lindskog U (1982) Acute intoxication with valproate. Lancet I:1306
Karlsen RL, Kett K, Henriksen O (1983) Intoxication with sodium valproate. Acta Med Scand 213:405–406
Klotz U, Antomin KH (1977) Pharmacokinetics and bioavailability of sodium valproate. Clin Pharmacol Ther 21:736–743
Koffler A, Friedler RM, Massry SG (1976) Acute renal failure due to nontraumatic rhabdomyolysis Ann Intern Med 85:23–28
Mortensen PB, Hansen HE, Pedersen B, Hartmann-Andersen F, Husted SE (1983) Acute valproate intoxication: biochemical investigations and hemodialysis treatment. Int J. Clin Pharmacol Ther Toxicol 21:64–68
Schnabel R, Rambeck B, Janssen F (1984) Fatal intoxication with sodium valproate. Lancet I:221–222
Steiman GS, Woerpel RW, Sherard ES (1979) Treatment of accidental sodium valproate, overdose with an opiate antagonist. Ann Neurol 6:274
Valproate (1987) Curr Probl Ped 17:177–209
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Roodhooft, A.M., Van Dam, K., Haentjens, D. et al. Acute sodium valproate intoxication: Occurrence of renal failure and treatment with haemoperfusion-haemodialysis. Eur J Pediatr 149, 363–364 (1990). https://doi.org/10.1007/BF02171569
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02171569