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On the presence of dihydroxyphenylalanine decarboxylase in nerves

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Zusammenfassung

Durchtrennung des Rückenmarks führt zu einer Verminderung der Aktivität des Enzymsl-3,4-Dihydroxyphenylalanin-decarboxylase (DOPA-Decarboxylase) in den kaudalen Teilen um 75% (in-vivo-Werte) bis 95% (in-vitro-Werte). Die Decarboxylaseaktivität in der Rattenmilz wird nach Exzision des Ganglion Coeliacum ebenfalls erheblich vermindert. Man kann daher annehmen, dass die DOPA-Decarboxylase in den absteigenden Rückenmarksnerven und in den sympathischen Nerven der Milz vorkommt.

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Authors and Affiliations

  1. Departments of Pharmacology, Universities of Göteborg and Lund, Sweden

    N. E. Andén, T. Magnusson & E. Rosengren

Authors
  1. N. E. Andén
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  2. T. Magnusson
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  3. E. Rosengren
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Additional information

This work was supported by grants from the National Institute of Neurological Diseases and Blindness (NB 04359-01), United States Public Health Service and the Swedish Medical Research Council.

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Andén, N.E., Magnusson, T. & Rosengren, E. On the presence of dihydroxyphenylalanine decarboxylase in nerves. Experientia 20, 328–329 (1964). https://doi.org/10.1007/BF02171078

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