Skip to main content
Log in

Role of interleukin-1 in 4-hydroperoxycyclophosphamide toxicity to bone marrow progenitor cells: A review

  • Published:
Biotherapy

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Dicke KA, Spitzer G. Evaluation of the use of high-dose cytoreduction with autologous marrow rescue in various malignancies (an overview). Transplantation 1986; 41: 4.

    PubMed  Google Scholar 

  2. Linch DC, Goldstone AH. Autologous bone marrow transplanation in acute leukemia (Review). Bone marrow Transplantation 1987; 2: 219.

    PubMed  Google Scholar 

  3. Gale RP. Bone marrow purging: current status, future directions. Bone Marrow Transplantation 1987; Suppl 2: 107.

    Google Scholar 

  4. Bronchud MH, Scarffe JH, Thatcher N, Crowther D, Souza LM, Alton NK, Testa NG, Dexter TM. Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Br J Cancer 1987; 56: 809.

    PubMed  Google Scholar 

  5. Morstyn G, Souza LM, Keech J, Sheridan W, Campbell L, Alton NK, Green M, Metcalf D, Fox R. Effect of granulocyte colony stimulating factor on neutropenia induced by cyctotoxic chemotherapy. Lancet 1988; 1: 667.

    PubMed  Google Scholar 

  6. Gabrilove JL, Jakubowski A, Scher H, Sternberg C, Wong G, Grous J, Yagoda A, Fain K, Moore MAS, Clarkson B, Oettgen HF, Alton K, Welte K, Souza L. Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium. N Engl J Med 1988; 318: 1414.

    PubMed  Google Scholar 

  7. Gabrilove JL, Jakubowski A, Fain K, Grous J, Scher H, Sternberg C, Yagoda A, Clarkson B, Bonilla MA, Oettgen HF, Alton K, Boone T, Altrok B, Welte K, Souza L. Phase I study of granulocyte colony-stimulating factor in patients with transitional cell carcinoma of the urothelium. J Clin Invest 1988; 82: 1454.

    PubMed  Google Scholar 

  8. Antman KS, Griffin JD, Elias A, Socinski MA, Ryan L, Cannistra SA, Oette D, Whitely M, Frei E III, Schnipper LE. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med 1988; 319: 593.

    PubMed  Google Scholar 

  9. Brandt SJ, Peters WP, Atwater SK, Kurtzberg J, Borowitz MJ, Jones RB, Shpall EJ, Bast RC, Jr., Gilbert CJ, Oette DH. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplanation. N Engl J Med 1988; 318: 869.

    PubMed  Google Scholar 

  10. Neumanaitis J, Singer JW, Buckner CD, Hill R, Storb R, Thomas ED, Appelbaum FR. Use of recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) in autologous marrow transplanation for lymphoid malignancies. Blood 1988; 72: 834.

    PubMed  Google Scholar 

  11. Blazer BR, Kersey JH, McGlave PB, Vallera DA, Lasky LC, Haake RJ, Bostrom B, Weisdorf DR, Epstein C, Ramsay NKG.In vivo administration of recombinant human granulocyte/macrophage colony-stimulating factor in acute lymphoblastic leukemia patients receiving purged autografts. Blood 1989; 73: 849.

    PubMed  Google Scholar 

  12. Neta R, Douches SD, Oppenheim JJ. Interleukin-1 is a radio-protector. J Immunol 1986; 136: 2483.

    PubMed  Google Scholar 

  13. Neta R, Sztein MB, Oppenheim JJ, Gillis S, Douches SD. Thein vivo effects of interleukin-1. 1. Bone marrow cells are induced to cycle after administration of interleukin-1. J Immunol 1987; 139: 1861.

    PubMed  Google Scholar 

  14. Schwartz GN, MacVittie TJ, Vigneulle RM, Patchen ML, Douches SD, Oppenheim JJ, Neta R. Enhanced hematopoietic recovery in irradiated mice pretreated with interleukin-1 (IL-1). Immunopharm and Immunotox 1987; 9: 371.

    Google Scholar 

  15. Neta R, Oppenhiem JJ, Douches SD. Interdependence of the radioprotective effects of human recombinant interleukin 1, tumor necrosis factor, granulocyte colony-stimulating factor, and murine recombinant granulocyt-macrophage colony-stimulating factor. J Immunol 1988; 140: 108.

    PubMed  Google Scholar 

  16. Castelli MP, Block PL, Schneider M, Pennington R, Abe F, Talmadge JE. Protective, resotative, and therapeutic properties of recombinant human IL-1 in rodent models. J Immunol 1988; 140: 3830.

    PubMed  Google Scholar 

  17. Moore MAS, Warren DJ. Synergy of interleukin-1 and granulocyte-macrophage colony-stimulating factor:in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-Fluorouracil treatment of mice. Proc Natl Acad Sci USA 1987; 84: 7134.

    PubMed  Google Scholar 

  18. Neta R, Oppenheim JJ, Douches SD, Giclas PC, Imbra RJ, Karin M. Radioprotection with IL-1. Comparison with other cytokines. In: Cinader B, Miller RG, eds. Progress of Immunology, VI. New York: Academic Press, 1986; 900–9.

    Google Scholar 

  19. Rosenthal M, Hodgson GS, Bradley TR. Organization of hematopoietic stem cells: The generation-age hypothesis. Cell Tissue Kinet 1979; 12: 17.

    PubMed  Google Scholar 

  20. Bradley TR, Hodgson GS. Detection of primitive macrophage progenitor cells in bone marrow. Blood 1979; 54: 1446.

    PubMed  Google Scholar 

  21. Bartelmez SH, Stanley E. Synergism between hemopoietic growth factors (HGFs) detected by their effects on cells bearing receptors for lineage specific HGF: Assay of hemopoietin 2. J Cell Physiol 1985; 122: 370.

    PubMed  Google Scholar 

  22. Bartelmez SH, Sacca R, Stanley E. Lineage specific receptors used to identify a growth factor for developementally early hemopoietic cells: Assay of hemopoietin 1. J Cell Physiol 1985; 122: 362.

    PubMed  Google Scholar 

  23. Stanley ER, Bartocci A, Partinkin D, Rosendaal M, Bradley TR. Regulation of very primitive, multipotent, hemopoietic cells by hemopoietin-1. Cell 1986; 45: 667.

    PubMed  Google Scholar 

  24. Michizuki DY, Eisenman JR, Conlon PJ, Larsen AD, Tushinski RJ. Interleukin-1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1. Proc Natl Acad Sci USA 1987; 84: 5267.

    PubMed  Google Scholar 

  25. Zsebo KM, Wypych J, Yuschenkoff VN, Lu H, Hunt P, Dukess PP, Langley KE. Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow. Blood 1988; 71: 962.

    PubMed  Google Scholar 

  26. McNiece I, Kriegher T, Quesenberry P. Stimulation of primitive progenitor cells by factors produced by 5637 cells: comparison to interleukin-1 alpha. (abstract). J Cell Biochem 1989; Suppl 13c: 16.

  27. Moore MAS, Warren DJ, Souza LM. Synergistic interaction between interleukin-1 and CSF's in hematopoiesis. In: Gale RP, Golde DW, eds. Recent Advances in Leukemia and Lymphoma. New York: Alan R. Liss, 1986: 445–56.

    Google Scholar 

  28. Bartelmez SH, Bradley TR, Bertoncello I, Mochizuki DY, Tushinski RJ, Stanley E, Hapel AJ, Young IG, Kriegler AB, Hodgson GS. Interleukin 1 plus interleukin 3 plus colony-stimulating factor 1 are essential for clonal proliferation of primitive myeloid bone marrow cells. Exptl Hematol 1989; 17: 240.

    Google Scholar 

  29. Moreb J, Zucali JR, Gross MA, Dinarello CA. Influence of interleukin 1 on human marrow blast progenitor cellsin vitro. In: Powanda MC, Oppenheim JJ, Kluger MJ, Dinarello CA. eds. Monokines and Non-lymphocytic Cytokines. New York: Alan R. Liss, 1988: 297–300.

    Google Scholar 

  30. Jubinsky PT, Stanley ER. Purification of hematopoietin 1: a multinlineage hemopoietic growth factor. Proc Natl Acad Sci USA 1985; 82: 2764.

    PubMed  Google Scholar 

  31. Sharkis SJ, Santos GW, Colvin M. Elimination of acute myelogenous leukemic cells from marrow and tumor suspensions in the rat with 4-hydroperoxycyclophosphamide. Blood 1980; 55: 521.

    PubMed  Google Scholar 

  32. Kaizer H, Stuart RK, Brookmeyer R, Beschorner WE, Braine HG, Burns WH, Fuller DJ, Korbling M, Mangan KF, Sarai R, Sensenbrenner LL, Shadduck RK, Shende AC, Tutschka PJ, Yeager AM, Zinkham WH, Santos GW. Autologous bone marrow transplanation in acute leukemia: A phase I study ofin vitro treatment of marrow with 4-hydroperoxycyclophosphamide to purge tumor cells. Blood 1985; 65: 1504.

    PubMed  Google Scholar 

  33. Yeager AM, Kaizer H, Santos GW, Sarai R, Colvin MO, Stuart RK, Braine HG, Burke RJ, Ambinder RF, Burns WH, Fuller DJ, Davis JM, Karp JE, Stratford WM, Rowley SD, Sensenbrenner LL, Vogelsang GB, Wingard JR. Autologous bone marrow transplanation in patients with acute non-lymphocytic leukemia, usingex vivo marrow treatment with 5-hydroperoxycyclophosphamide. N Engl J Med 1986; 315: 141.

    PubMed  Google Scholar 

  34. Kohn FR, Sladek NE. Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines. Biochem Pharmacol 1985; 34: 3465.

    PubMed  Google Scholar 

  35. Sladek NE, Landamer GJ. Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase acitivity in cultured oxazaphosphorine-resistant L1210 and cross-linking agent-resistant P388 cell lines. Cancer Res 1985; 45: 1549.

    PubMed  Google Scholar 

  36. Rowley SD, Colvin MO, Stuart RK. Human multilineage progenitor cell sensitivity to 4-hydroperoxycyclophosphamide. Exptl Hematol 1985; 13: 295.

    Google Scholar 

  37. Moreb J, Zucali JR, Gross MA, Weiner RS. Protective effects of IL-1 on human hematopoietic progenitor cells treatedin vitro with 4-hydroperoxycyclophosphamide. J Immun 1989; 142: 1937.

    PubMed  Google Scholar 

  38. Monette FC, Signounas G. Growth of murine multipotent stem cells in a simple “serum free” culture system: Role of interleukin-3, erythropoietin, and hemin. Exptl Hematol 1988; 16: 250.

    Google Scholar 

  39. Williams DE, Hangoc G, Cooper S, Boswell HS, Shadduck RK, Gillis SK, Waheed S, Urdal D, Broxmeyer HE. The effects of purified recombinant murine interleukin-3 and/or purified natural murine CSF-1in vivo on the proliferation of murine high- and low-proliferatioe potential colony-forming cells: Demonstration ofin vivo synergism. Blood 1987; 70: 401.

    PubMed  Google Scholar 

  40. Leary AG, Yang Y-C, Clark SC, Gasson JC, Golde DW, Ogawa M. Recombinant gibbon interleukin 3 supports formation of human multilineage colonies and blast cell colonies in culture: Comparison with recombinant human granulocyte-macrophage colony-stimulating factor. Blood 1987; 70: 1343.

    PubMed  Google Scholar 

  41. Koike K, Stanley E, Ihle JN, Ogawa M. Macrophage colony formation supported by purified CSF-1 and/or interleukin 3 in serum free culture: Evidence for hierarchial difference in macrophage colony-forming cells. Blood 1986; 67: 859.

    PubMed  Google Scholar 

  42. Sieff CA, Niemeyer CM, Nathan DG, Ekem SC, Bieber FR, Yang Y-C, Wong G, Clark SC. Stimulation of human hematopoietic colony formation by recombinant gibbon multi-colony-stimulating factor or interleukin 3. J Clin Invest 1987; 80: 818.

    PubMed  Google Scholar 

  43. Moreb J, Zucali JR, Weiner RS. The role of interleukin 3 and interleukin 6 in the protection from 4-hydroperoxy-cyclophosphamide and the proliferation of early hematopoietic progenitor cells. Exptl Hematol 1989; in press.

  44. Van Damme J, Cayphas S, Opdenakker G, Bilian A, Van Snich J. Interleukin 1 and poly (r1), poly (rC) induce production of a hybridoma growth factor by fibroblasts. Eur J Immunol 1987; 17: 1.

    PubMed  Google Scholar 

  45. Kohase M, May LT, Tamm I, Vilcek J, Sehgal PB. A cytokine network in human diploid fibroblasts: Interactions of B interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1. Mol Cell Biol 1987; 7: 273.

    PubMed  Google Scholar 

  46. Billiau A. Interferon B2 as a promoter of growth and differentiation of B cells. Immunology Today 1987; 8: 84.

    Google Scholar 

  47. Yang YC, Tsai S, Wong GG, Clark SC. Interleukin 1 regulation of hematopoietic growth factor production by human stromal fibroblasts. J Cell Physiol 1988; 134: 292.

    PubMed  Google Scholar 

  48. Neta R, Vogel SN, Sipe JD, Wong GG, Nordan RP. Comparison ofin vivo effects of human recombinant IL-1 and human recombinant IL-6 in mice. Lymphokine Res 1988; 7: 403.

    PubMed  Google Scholar 

  49. Slordal L, Warren DJ, Moore MA. Effects of recombinant murine tumor necrosis factor on hemopoietic reconstitution in sublethally irradiated mice. J Immunol1989; 142: 833.

    PubMed  Google Scholar 

  50. Le J, Vilcek J. Biology of Disease. Tumor necrosis factor and interleukin-1: Cytokines with multiple overlapping biological activities. Lab Invest 1987; 56: 234.

    PubMed  Google Scholar 

  51. Dinarello CA, Ikejima T, Warner SJC, Oreneole SF, Lonnemann G, Cannon JG, Libby P. Interleukin 1 induces interleukin 1. 1. Induction of circulating interleukin 1 in rabbitsin vivo and in human mononuclear cellsin vitro. J Immunol 1987; 139: 1902.

    PubMed  Google Scholar 

  52. Ikebuchi K, Wong GG, Clark SC, Ihle JN, Hirai Y, Ogawa M. Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci USA 1987; 84: 9035.

    PubMed  Google Scholar 

  53. Philip R, Epstein LB. Tumor necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, gamma interferon and interleukin-1. Nature 1986; 323: 86.

    PubMed  Google Scholar 

  54. Zucali JR, Dinarello CA, Oblon DJ, Gross MA, Anderson L, Weiner RS. Interleukin-1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2. J Clin Invest 1986; 77: 1857.

    PubMed  Google Scholar 

  55. Zucali JR, Broxmeyer HE, Dinarello CA, Gross MA, Weiner RS. Regulation of early human hematopoietic (BFU-E and CU-GEMM) progenitor cellsin vitro by interelukin 1-induced fibroblast-conditioned medium. Blood 1987; 69: 33.

    PubMed  Google Scholar 

  56. Bagby GC, Dinarello CA, Wallace P, Wagner C, Hefeneider S, McCall E. Interleukin 1 stimulates granulocyte macrophage colony-stimulating activity release by vascular endothelial cells. J Clin Invest 1987; 78: 1316.

    Google Scholar 

  57. Sieff CA, Tsai S, Faller DV. Interleukin-1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor. J Clin Invest 1987; 79: 48.

    PubMed  Google Scholar 

  58. Rennick D, Yang G, Gemmell L, Lee F. Control of hemopoiesis by a bone marrow stromal cell clone: lipopolysaccharide and interleukin-l-inducible production of colony-stimulating factors. Blood 1987; 69: 682.

    PubMed  Google Scholar 

  59. Broudy JC, Kaushansky K, Harlan JM, Adamson JW. Interleukin-1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor. J Immunol 1987; 139: 464.

    PubMed  Google Scholar 

  60. Curt GA, Clendennin N, Chabner BA. Drug resistance in cancer. Cancer Treat Rep 1984; 68: 87.

    PubMed  Google Scholar 

  61. Sahovic EA, Colvin M, Hilton J, Ogawa M. Role of aldehyde dehydrogenase in survival of progenitors for murine blast cell colonies after treatment with 4-hydroperoxycyclophosphamidein vitro. Cancer Res 1988; 48: 1223.

    PubMed  Google Scholar 

  62. Zucali JR, Moreb J, Weiner RS, Gross MA, Green V, Duncan B. Fractionation of early hematopoietic progenitor cells from human bone marrow by elutriation centrifugation and immunomagnetic beads. (abstract). Exptl Hematol 1988; 16: 437.

    Google Scholar 

  63. Onozaki K, Matsushima K, Aggarwal BB, Oppenheim JJ. Human interleukin-1 is a cytocidal factor for several tumor cell lines. J Immunol 1985; 135: 3692.

    Google Scholar 

  64. Lovett D, Kozan B, Hadam M, Resch K, Gemsa D. Macrophage cytotoxicity: interleukin 1 as a mediator of tumor cytostasis. J Immunol 1986; 136: 340.

    PubMed  Google Scholar 

  65. Nakmura S, Nakata N, Kashimoto S, Yoshida H, Yamada M. Antitumor effect of recombinant human interleukin-1 alpha against murine syngeneic tumors. Jpn J Cancer Res 1986; 77: 767.

    PubMed  Google Scholar 

  66. Moreb J, Zucali JR, Gross MA, Weiner RS. Preincubation with interleukin 1 increases the cytotoxicity of 4-hydroperoxycyclophosphamide toward leukemic cells while protecting normal human hematopoietic progenitor cells. (abstract). Blood 1988; 72: 398a.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moreb, J., Zucali, J.R. Role of interleukin-1 in 4-hydroperoxycyclophosphamide toxicity to bone marrow progenitor cells: A review. Biotherapy 1, 273–280 (1989). https://doi.org/10.1007/BF02171003

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02171003

Key words

Navigation