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Isolation of crystalline aldosterone from the urine of a nephrotic patient

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Zusammenfassung

Es ist erstmals gelungen, Aldosteron aus menschlichem Urin zu isolieren. Eine Fraktion des 13-Tage-Harnes von einem Knaben mit Nephrose und massiven Ödemen ergab 1,0 mg dieses biologisch hochaktiven Hormons in kristallisierter Form. Da der Gesamtgehalt gegen 3 mg betrug, stellt solcher Harn ein geeignetes Ausgangsmaterial dar zur extraktiven Gewinnung von Aldosteron. Letzteres erwies sich in seinen Eigenschaften als identisch mit Aldosteron aus Rinder-Nebennieren.

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Authors and Affiliations

  1. Stanford University School of Medicine, San Francisco, California

    J. A. Luetscher Jr., R. Neher & A. Wettstein

  2. Research Laboratories of Ciba Ltd., Basle, Switzerland

    R. Neher & A. Wettstein

Authors
  1. J. A. Luetscher Jr.
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  2. R. Neher
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  3. A. Wettstein
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Luetscher, J.A., Neher, R. & Wettstein, A. Isolation of crystalline aldosterone from the urine of a nephrotic patient. Experientia 10, 456–458 (1954). https://doi.org/10.1007/BF02170397

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