Skip to main content
SpringerLink
Log in

Cytokines in radioprotection and therapy of radiation injury

  • Published:
Biotherapy

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Elkind MM. Repair processes in radiation biology. Radiat Res 1984; 100: 425.

    PubMed  Google Scholar 

  2. Behling UH. The radioprotective effect of bacterial endotoxin. In: Nowotny A (ed.) Beneficial Effects of Endotoxins. New York: Plenum Press, 1983; p. 127.

    Google Scholar 

  3. Boggs SS, Chervenick PA, Boggs DR. The effect of postirradiation bleeding or endotoxin on proliferation and differentiation of hematopoietic stem cells. Blood 1972; 40: 375.

    PubMed  Google Scholar 

  4. Metcalf D. The molecular biology and functions of the granulocyte-macrophage colony stimulating factor. Blood 1986; 76: 257–267.

    Google Scholar 

  5. Neta R, Douches SD, Oppenheim JJ. Interleukin-1 is a radioprotector. J Immunol 1986; 136: 2483–2485.

    PubMed  Google Scholar 

  6. Neta R, Douches SD, Oppenheim JJ. Radioprotection by interleukin-1. In: Goldstein F, Bach JF, Wigzal H (eds) Immunoregulation by Characterized Polypeptides. UCLA Symposia on Molecular and Cellular Biology 1986; 41: 429–441.

  7. Neta R, Oppenheim JJ, Douches SD. Interdependence of the radioprotective effects of human recombinant IL-1, TNF, G-CSF, and murine recombinant G-CSF. J Immunol 1988; 140: 108–111.

    PubMed  Google Scholar 

  8. Dinarello CA. Interleukin-1. Rev Infect Dis 1984; 6: 51–95.

    PubMed  Google Scholar 

  9. Durum SK, Oppenheim JJ, Neta R. Immunophysiological role of interleukin 1. In: Oppenheim JJ, Shevach E (eds) Immunophysiology: Role of Cells and Cytokines in Immunity and Inflammation. New York: Oxford University Press, in press.

  10. Walden TL Jr, Patchen ML, Snyder SL. 16,16-Dimethylprostaglandin E increases survival in mice following irradiation. Radiat Res 1987; 109: 540–549.

    Google Scholar 

  11. Neta R, Oppenheim JJ, Douches SD, Giclas PC, Imbra RJ, Karin M. Radioprotection with IL-1. Comparison with other cytokines. In: Cinader B, Miller RG (eds) Progress of Immunology, VI. New York: Academic Press, 1986; pp. 900–909.

    Google Scholar 

  12. Neta R, Sztein MB, Oppenheim JJ, Gillis S, Douches SD.In vivo effects of IL-1. 1. Bone marrow cells are induced to cycle following administration of IL-1. J Immunol 1987; 139: 1861–1866.

    PubMed  Google Scholar 

  13. Denekamp J. Cell kinetics and radiation biology. Int J Radiat Biol 1986; 49: 357.

    Google Scholar 

  14. Ramadori G, Sipe JD, Dinarello CA, Mizel SB, Colten HR. Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin-1 (IL-1) and purified human IL-1. J Exp Med 1985; 162: 930–942.

    PubMed  Google Scholar 

  15. Sipe JD, Vogel SN, Douches SD, Neta R. Tumor necrosis factor/cachectin is a less potent inducer of serum amyloid a synthesis than interleukin-1. Lymphokine Res 1987; 93–101.

  16. Mortensen RF, Shapiro J, Lin B-F, Douches SD, Neta R. Interaction of recombinant Interleukin-l (IL-1) and recombinant tumor necrosis factor (TNF) in the induction of mouse acute phase proteins. J Immunol 1988; 140: 2260–66.

    PubMed  Google Scholar 

  17. Karin M. Metallothioeins: proteins in search of function. Cell 1985; 41: 9–11.

    PubMed  Google Scholar 

  18. Goldstein IM, Charo IF. Ceruloplasmin: an acute phase reactant and antioxidant. In: Pick E (ed.) Lymphokines, 8. New York: Academic Press, 1983; pp. 373–411.

    Google Scholar 

  19. Vogel SN, Douches SD, Kaufman EN, Neta R. Induction of colony stimulating factorin vivo by recombinant interleukin-I and recombinant tumor necrosis factor. J Immunol 1987; 138: 2143–48.

    PubMed  Google Scholar 

  20. Neta R., Vogel SN, Oppenheim JJ, Douches SD. Cytokines in radioproteciton. Comparison of the radioprotective effects of IL-1 to IL-2, GM-CSF and IFN. Lymphokine Res 1986; 5: 5105–5110.

    Google Scholar 

  21. Moore MAS, Warren DJ. Synergy of interleukin-I and granulocyte colony-stimulating factor:In vivo stimulation of stem cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice. Proc Natl Acad Sci USA 1987; 84: 7134–38.

    PubMed  Google Scholar 

  22. Sieff CA. Hematopoietic growth factors. J Clin Invest 1987; 79: 1549–57.

    PubMed  Google Scholar 

  23. Groopman JE. Hematopoietic growth factors: from methyl cellulose to man. Cell 1987; 50: 5–6.

    Google Scholar 

  24. Cohen AM, Zsebo KM, Inoue H, Hines D, Boone TC, Chazin VR, Tsai L, Ritch T, Souza LM.In vivo stimulation of granulopoiesis by recombinant human granulocyte colony stimulating factor. Proc Natl Acad Sci USA 1987; 84: 2484–88.

    PubMed  Google Scholar 

  25. Shimanura M, Kobayashi Y, Yno A, Urabe A, Okabe T, Komatsu Y, Itoh S, Takaku F. Effect of human recombinant granulocyte colony stimulating factor on hematopoietic injury in mice induced by r-fluorouracil. Blood 1987; 69: 353–55.

    PubMed  Google Scholar 

  26. Nienhuis AW, Donahue RE, Karlsson S, Clark SC, Agricola B, Antinoff N, Pierce JE, Turner P, Anderson WF, Nathan DG. Recombinant human GM-CSF shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. J Clin Invest 1987; 80: 573–77.

    PubMed  Google Scholar 

  27. Monroy RL, Skelly RR, MacVittie TJ, Davis TA, Sauber JJ, Clark SC, Donahue RE. The effect of recombinant GM-CSF on the recovery of the monkeys transplanted with autologous bone marrow. Blood 1987; 70: 1996–99.

    Google Scholar 

  28. Neta R, Oppenheim JJ. Cytokines in therapy of radiation injury. Blood 1988; 72: 1093–95.

    PubMed  Google Scholar 

  29. Bond VP, Fliedner TM, Archambeau JO. Mammalian Radiation Lethality. A Disturbance in Cellular Kinetics. New York: Academic Press, 1965.

    Google Scholar 

  30. Nakamura S, Nakata K, Kashimoti S, Yoshida H, Yamada M. Antitumor effect of recombinant human interleukin-1 alpha against murine syngeneic tumors. Jpn J Canc Res 1986; 77: 767.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Armed Forces Radiobiology Research Institute, 20814, Bethesda, MD, USA

    Ruth Neta

Authors
  1. Ruth Neta
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Neta, R. Cytokines in radioprotection and therapy of radiation injury. Biotherapy 1, 41–45 (1989). https://doi.org/10.1007/BF02170134

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02170134

Keywords

Search

Navigation