Skip to main content
SpringerLink
Log in

The control of proliferation and differentiation of early erythroid progenitors

  • Published:
Biotherapy

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. McCulloch EA. Stem cells in normal and leukemic hematopoiesis. Blood 1983; 62: 1–13.

    Google Scholar 

  2. Ogawa M, Porter PN, Nakahata T. Renewal and commitment of differentiation of hemopoietic stem cells. Blood 1983; 61: 823–9.

    Google Scholar 

  3. Eaves CJ, Eaves AC. Erythropoietin (Ep) dose-response curves for three classes of erythroid progenitors in normal human marrow and in patients with polycythemia vera. Blood 1978; 52: 1196–1210.

    Google Scholar 

  4. Van Zant G, Goldwasser E. Simultaneous effects of erythropoietin and colony-stimulating factor on bone marrow cells. Science 1977; 198: 773–5.

    Google Scholar 

  5. Korn AP, Henkelman RP, Ottensmeyer RP, Till JE. Investigations of a stochastic model of hemopoiesis. Exp Hemat 1973; 1: 362–75.

    Google Scholar 

  6. Eaves CJ, Humphries RK, Eaves AC. In vitro characterization of erythroid precursor cells and the erythropoietic differentiation process. In: Stamatoyannopoulos G. Nienhuis AW, eds., Cellular and Molecular Regulation of Hemoglobin Switching. New York, Grune and Stratton, 1979: 251–78.

    Google Scholar 

  7. Iscove NN. Erythropoietin-independent stimulation of early erythropoiesis in adult marrow cultures by conditioned media from lectin-stimulated mouse spleen cells. In: Globe DW, Cline MJ, Metcalf D, Fox CF, eds., Hematopoietic cell differentiation. New York: Academic Press, 1978: 37–52.

    Google Scholar 

  8. Aye MT. Erythroid colony formation in culture of human marrow: effect of leukocyte conditioned medium. J Cell Physiol 1977; 91: 69–73.

    Google Scholar 

  9. Linch DC, Nathan DG. T cell and monocyte-derived burst-promoting activity directly act on erythroid progenitor cells. Nature 1984; 312: 775–7.

    Google Scholar 

  10. Linch DC, Lipton JM, Nathan DG. Identification of three accessory cell populations in human bone marrow with erythroid burst-promoting properties. J Clin Invest 1985; 75: 1278–84.

    Google Scholar 

  11. Iscove NN, Guilbert LJ. Erythropoietin-independene of early erythropoiesis and a two-regulator model of proliferative control in the hemopoietic system. In: Murphy, MJ Jr, ed. In vitro aspects of erythropoiesis, New York, Springer-Verlag. 1978: 3–7.

    Google Scholar 

  12. Wagemaker G. Erythropoietin-independent regulation of early erythropoiesis. In: Rossi GB, ed.In vivo andin vitro erythropoiesis: the Friend system. Amsterdam, Elsevier, 1980: 87–96.

    Google Scholar 

  13. Dukes PP, Ma A, Clemons GK, Meytes D. Measurement of human erythroid burst-promoting activity by a specific cell culture assay. Exp Hematol 1985; 13: 59–65.

    Google Scholar 

  14. Donahue RE, Emerson SG, Wang EA, Wong GG, Clark SC, Nathan DG. Demonstration of burst-promoting activity of recombinant human GM-CSF on circulating erythroid progenitors using an assay involving the delayed addition of erythropoietin. Blood 1985; 66: 1479–81.

    Google Scholar 

  15. Metcalf D. The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors. Blood 1986; 67: 257–67.

    Google Scholar 

  16. Clark SC, Kamen R. The human hematopoietic colonystimulating factors. Science 1987; 236: 1229–36.

    Google Scholar 

  17. Sieff CA. Hematopoietic growth factors. J Clin Invest 1987; 79: 1549–57.

    Google Scholar 

  18. Sieff CA, Emerson SG, Donahue RE, Nathan DG, Wang EA, Wong GG, Clark SC. Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hemopoietin. Science 1985; 230: 1171–3.

    Google Scholar 

  19. Kaushansky K, O'Hara PJ, Berkner K, Segal GM, Hagen FS, Adamson JW. Genomic cloning, characterization, and multi-lineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci USA 1986; 83: 3101–5.

    Google Scholar 

  20. Migliaccio AR, Bruno M, Migliaccio G. Evidence for direct action of human biosynthetic (recombinant) GMCSF on erythroid progenitors in serum-free culture. Blood 1987; 70: 1867–71.

    Google Scholar 

  21. Yang Y-C, Ciarletta AG, Temple PA, Chung MP, Kovaviv S, Witek-Giannotti JS, Leary AC, Kruz R, Donahue RE, Wong GG, Clark SC. Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. Cell 1986; 47: 3–10.

    Google Scholar 

  22. Sonoda Y, Yang Y-C, Wong GG, Clark SC, Ogawa M. Analysis in serum-free culture of the targets of recombinant human hemopoietic growth factors: interleukin 3 and granulocyte/macrophage-colony stimulating factor are specific for early developmental stages. Proc Natl Acad Sci USA 1988; 85: 4360–4.

    Google Scholar 

  23. Migliaccio G, Migliaccio AR, Adamson JW. In vitro differentiation of human granulocyte/macrophage and erythroid progenitors: Comparative analysis of the influence of recombinant human erythropoietin, G-CSF, GM-CSF, and IL-3 in serum-supplemented and serum deprived cultures. Blood 1988; 72: 248–56.

    Google Scholar 

  24. Peschel C, Paul WE, Ohara J, Green I. Effects of B cell stimulatory factor- 1/interleukin 4 on hematopoietic progenitor cells. Blood 1987; 70: 254–63.

    Google Scholar 

  25. Kishi K, Ihle JN, Urdal DL, Ogawa M. Murine B-cell stimulatory factor-1 (BSF-1)/interleukin-4 (IL-4) is a multilineage colony-stimulating factor that acts directly on primitive hemopoietic progenitors. J Cell Physiol 1989; 139: 463–8.

    Google Scholar 

  26. Delwiche F, Raines E, Powell J, Ross R, Adamson JW. Platelet-derived growth factor enhancesin vitro erythropoiesis via stimulation of mesenchymal cells. J Clin Invest 1985; 76: 137–42.

    Google Scholar 

  27. Schaafsma MR, Falkenburg JHF, Duinkerken N, Van Damme J, Altrock BW, Willemze R, Fibbe W. Interleukin-1 synergizes with granulocyte-macrophage colonystimulating factor on granulocytic colony formation by intermediate production of granulocyte colony-stimulating factor. Blood 1989; 74: 2398–2404.

    Google Scholar 

  28. Yu J, Shao L, Vaughan J, Vale W, Yu AL. Characterization of the potentiation effect of activin on human erythroid colony formationin vitro. Blood 1989; 73: 952–60.

    Google Scholar 

  29. Broxmeyer HE, Lu L, Cooper S, Schwall RH, Mason AJ, Nikolics K. Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin. Proc Natl Acad Sci USA 1988; 85: 9052–6.

    Google Scholar 

  30. Sonoda Y, Yang Y-C, Wong GG, Clark SC, Ogawa M. Erythroid burst-promoting activity of purified recombinant human GM-CSF and interleukin-3: studies with antiGM-CSF and anti-IL3 sera and studies in serum-free cultures. Blood 1988; 72: 1381–6.

    Google Scholar 

  31. Feldman L, Dainiak N. B-lymphocyte-derived erythroid burst-promoting activity is distinct from other known lymphokines. Blood 1989; 73: 1814–20.

    Google Scholar 

  32. Migliaccio G, Migliaccio AR, Ruscetti S, Adamson JW. The growth of Rauscher erythroleukemia cells is mediated by autocrine production of a factor with biological activity similar to Interleukin-3. Blood 1989; 73: 1170–7.

    Google Scholar 

  33. Migliaccio G, Migliaccio AR, Adamson JW. The biology of hematopoietic growth factors: studiesin vitro under serum-deprived conditions. Exp Hemat, in press.

  34. Dainiak N, Kreczko S. Interactions of insulin, insulinlike growth factor II, and platelet-derived growth factor in erythropoietic culture. J Clin Invest 1985; 76: 1237–42.

    Google Scholar 

  35. Migliaccio AR, Migliaccio G. Human embryonic hemopoiesis: Control mechanisms underlying progenitor differentiationin vitro. Dev Biol 1988; 125: 127–34.

    Google Scholar 

  36. Akahane K, Tojo A, Urabe A, Takaku F. Pure erythropoietic colony and burst formations in serum free culture and their enhancement by insulin-like growth factor. Exp Hematol 1987; 15: 797–802.

    Google Scholar 

  37. Migliaccio AR, Migliaccio G, Adamson JW. Effect of recombinant hematopoietic growth factors on proliferation of human marrow progenitor cells in serum-deprived liquid culture. Blood 1988; 72: 1387–92.

    Google Scholar 

  38. Smith KA. Regulation of normal and neoplastic T cell growth. In: Cancer Cells 3/Growth Factors and Transformation. Cold Springs Harbor, NY: Cold Springs Harbor Laboratory, 1985; pp 205–10.

    Google Scholar 

  39. O'Keefe EJ, Pledger WJ. A model for cell cycle control: sequential events regulated by growth factors. Mol Cell Endocrinol 1983; 31: 167–86.

    Google Scholar 

  40. Spivak JL, Smith RRL, Ihle JN. Interleukin 3 promotes thein vitro proliferation of murine pluripotent hematopoietic stem cell. J Clin Invest 1985; 76: 1613–21.

    Google Scholar 

  41. Migliaccio AR, Visser JWM. Proliferation of purified murine hemopoietic stem cells in serum-free cultures stimulated with purified stem-cell-activating factor. Exp Hematol 1986; 14: 1043–8.

    Google Scholar 

  42. Metcalf D. Multi-CSF-dependent colony formation by cells of a murine hemopoietic cell line: specificity and action of multi-CSF. Blood 1985; 65: 357–62.

    Google Scholar 

  43. Kelvin DJ, Chance S, Shreeve M, Axelrad AA, Connolly JA, McLeod D. Interleukin 3 and cell cycle progression. J Cell Physiol 1986; 127: 403–9.

    Google Scholar 

  44. Ihle JN and Weinstein Y. Immunological Regulation of hematopoietic/lymphoid stem cell differentiation by interleukin 3. Advances in Immunology 1986; 39: 1–50.

    Google Scholar 

  45. Migliaccio G, Migliaccio AR, Visser JWM. Synergism between erythropoietin and interleukin-3 in the induction of hematopoietic stem cell proliferation and erythroid burst formation. Blood 1988; 72: 944–51.

    Google Scholar 

  46. Tang BD, Goldwasser E. The formation of erythrocyte membrane proteins during induced differentiation. J Biol Chem 1981; 256: 12666–72.

    Google Scholar 

  47. Papayannopoulou Th, Brice M, Stamatoyannopoulos G. Stimulation of fetal hemoglobin synthesis in bone marrow cultures from adult individuals. Proc Natl Acad Sci USA 1976; 73: 2033–7.

    Google Scholar 

  48. Kidoguchi K, Ogawa M, Karam JD, Martin AG. Augmentation of fetal hemoglobin (HbF) synthesis in culture by human erythropoietic precursors in the marrow and peripheral blood: studies in sickle cell anemia and nonhemoglobinopathic adults. Blood 1978; 52: 1115–24.

    Google Scholar 

  49. Nathan DG, Alter BP, Forget BG, Hillman DG, Housman D. Hemoglobin synthesis in human BFU-E and CFU-E-derived colonies. Blood 1979; 54: 805–17.

    Google Scholar 

  50. De Simone J, Heller P, Hall L, Zwiers D. 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons. Proc Natl Acad Sci USA 1982; 79: 4428–32.

    Google Scholar 

  51. Comi P, Ottolenghi S, Giglioni B, Migliaccio G, Migliaccio AR, Bassano E, Amadori S, Mastroberardino G, Peschle C. Bromodeoxyuridine treatment of normal adult erythroid colonies: anin vitro model for reactivation of human fetal globin genes. Blood 1986; 68: 1036–41.

    Google Scholar 

  52. Migliaccio AR, Migliaccio G, Constantoulakis P, Stamatoyannopoulos G, Papayannopoulou Th. Influence of recombinant hemopoietins and of fetal calf serum on the globin synthetic pattern of human BFUe. Blood submitted.

  53. Tsai SF, Martin DIK, Zon LI, D'Andrea AD, Wong GG, Orkin SH. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature 1989; 339: 446–51.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Hematopoietic Growth Factors, New York Blood Center, New York, NY, USA

    Anna Rita Migliaccio & Giovanni Migliaccio

Authors
  1. Anna Rita Migliaccio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Giovanni Migliaccio
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Migliaccio, A.R., Migliaccio, G. The control of proliferation and differentiation of early erythroid progenitors. Biotherapy 2, 299–303 (1990). https://doi.org/10.1007/BF02170079

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02170079

Keywords

Search

Navigation