Summary
The ATPase activity is inhibited by Colchicin in concentrations of 10−3 m and 10−4 m at a rate of 40 to 20 %, but in no way in the range of 10−7 m and 10−8 m, where Colchicin exerts its typical spindle-blocking action on the mitotic cell division. It is therefore no evidence, that Colchicin acts by influence on the energy yielding ATP-ATPase system, which was proposed to be responsible for the spindle contraction.
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Literatur
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Lang, K., Siebert, G. & Estelmann, W. Hemmung der Adenosintriphosphatase durch Colchicin. Experientia 7, 379–380 (1951). https://doi.org/10.1007/BF02168908
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DOI: https://doi.org/10.1007/BF02168908