Summary
With the aid of the tensiometer, it can be proved that histamine reacts in a specific manner with primary phosphoric acid esters. This proof is brought about by strongly increasing the capillary activity of cetyl phosphate by histamine on the interface chloroform water. The mechanism of this reaction is discussed. Simple secondary phosphoric acid esters and bi-secondary phosphoric acid esters are not influenced under the same conditions. A pronounced antagonistic effect of calcium ions antihistamine compounds may be proved with the same assays.
The point of attack of these compounds is the phosphate and not the histamine. The results of the tests confirm the assumption that the mode of action of the histamine and of the antihistamine compounds is connected with primary phosphoric acid esters.
This is a preview of subscription content, log in via an institution to check access.
References
R. Hirt et al., Arzneimittelforschung2, 453 (1952);3, 175, 297 (1953);4, 372 (1954).
G. M. Kosolapoff, J. Amer. chem. Soc.74, 3427 (1952); J. chem. Soc. London1950, 3535.
J. F. Danielli, Proc. Roy. Soc. London122 B, 155 (1937).
J. F. Danielli, Proc. Roy. Soc. London122 B, 155 (1937).
R. Hirt et al., Arzneimittelforschung2, 453 (1952);3, 175 297 (1953);4, 372 (1954).
R. Hirt et al., Arzneimittelforschung2, 453 (1952);3, 175, 297 (1953);4, 372 (1954).
G. Perlmann, Biochem. Biophys. acta13, 452 (1954); J. Amer. chem. Soc.74, 3191 (1952); Nature174, 273 (1954).
A. W. D. Avison et al., Quart. Rev.5, 717 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hirt, R., Berchtold, R. Zum Wirkungsmechanismus des Histamins. Experientia 11, 273–275 (1955). https://doi.org/10.1007/BF02161253
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02161253