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Interaction of serotonin and lysergic acid diethylamide (LSD) in the central nervous system

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Zusammenfassung

Serotonin (5-Oxytryptamin) wirkt bei der Maus als mildes Sedativum und steigert den hypnotischen Effekt von Evipan deutlich. Diese Wirkungssteigerung kann durch Lysergsäure-diäthylamid (LSD) antagonisiert werden. Dieser Befund stimmt mit der Ansicht überein, dem Serotonin komme eine physiologische Rolle im Gehirn zu und dass LSD möglicherweise durch antagonistische Wirkung gegenüber Serotonin Psychose verursachen kann.

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Literatur

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Authors and Affiliations

  1. Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education and Welfare, Bethesda, Md.

    P. A. Shore, S. L. Silver & B. B. Brodie

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  1. P. A. Shore
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  2. S. L. Silver
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  3. B. B. Brodie
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Shore, P.A., Silver, S.L. & Brodie, B.B. Interaction of serotonin and lysergic acid diethylamide (LSD) in the central nervous system. Experientia 11, 272–273 (1955). https://doi.org/10.1007/BF02161252

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  • DOI: https://doi.org/10.1007/BF02161252

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