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Total synthesis of two cyclodecapeptides exerting polymyxin-like activity

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Zusammenfassung

Von den vier Cyclodekapeptiden, die als mögliche Strukturen für Polymyxin B1 vorgeschlagen wurden, konnten nun auch die Ringstrukturen mit 7 Aminosäuren, nämlich 7γ und 7α (vgl. Fig.), synthetisiert werden. Diese erwiesen sich im Gegensatz zu 8γ und 8α als hochaktive antimikrobielle Wirkstoffe mit Wirkungsqualitäten der Polymyxine. Ob 7γ oder 7α mit natürlichem Polymyxin B1 identisch ist, wird durch weitere Versuche abgeklärt.

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Authors and Affiliations

  1. Forschungsabteilung der F. Hoffmann-La Roche & Co. A.G., Basel

    K. Vogler, R. O. Studer, P. Lanz, W. Lergier & Erika Böhni

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  1. K. Vogler
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  2. R. O. Studer
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  3. P. Lanz
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  4. W. Lergier
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  5. Erika Böhni
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Vogler, K., Studer, R.O., Lanz, P. et al. Total synthesis of two cyclodecapeptides exerting polymyxin-like activity. Experientia 17, 223–224 (1961). https://doi.org/10.1007/BF02160629

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