Abstract
Cells of human choroidal melanoma were implanted in the cornea of rabbits. A few days later corneal neovascularization onto the tumor can be observed. When the tumor is vascularized, rapid tumor growth follows. Macroscopic, histologic, and angiographic aspects are presented. The role of prostaglandin E2 (PGE2) as a cause of angiogenesis is discussed.
Zusammenfassung
Humane Aderhautmelanomzellen wurden in Kaninchenhornhäute implantiert. Nach wenigen Tagen ist eine auf den Tumor gerichtete korneale Neovasularisation zu beobachten. Sobald das Implantat vaskularisiert ist, kommt es zu einem explosionsartigen Tumorwachstum. Makroskopische, mikroskopische und fluoreszenzangiographische Befunde werden dargestellt. Die Rolle des Prostaglandins E2 (PGE2) als kausaler Angiogenesefaktor wird diskutiert.
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Herrn Prof. Dr. A. Nover zum 60. Geburtstag gewidmet
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Rochels, R. Experimentelle Untersuchungen zur Tumorangiogenese. Graefe's Arch Clin Exp Ophthalmol 219, 20–23 (1982). https://doi.org/10.1007/BF02159974
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DOI: https://doi.org/10.1007/BF02159974