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Über das Verhalten von Riboflavin-Semichinon gegen Metallionen. Modellstudien zur Metall-Flavoenzymkatalyse

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Summary

The specific metal-chelating properties of the flavoenzymes are not to be interpreted by the metal affinities of riboflavin (Rfl) and leukoriboflavin (RflH2), but by those of the semiquinoid radical (RflH). The reaction of RflH with metal ions gives rise to the formation of chelates that are well characterisable by potentiometric and spectrophotometric analysis. By the chelation, the semiquinoid level of the ligand is stabilised in the thermodynamic as well as in the kinetic sense.

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Authors and Affiliations

  1. Anorganisch-chemische Anstalt der Universität Basel, Switzerland

    P. Hemmerich

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  1. P. Hemmerich
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Ich danke Herrn Prof.H. Erlenmeyer für sein Interesse an dieser Arbeit und dem Schweizerischen Nationalfonds zur Förderung der wissenschaftlichen Forschung für materielle Unterstützung. Den Herren Prof.H. A. Harbury, Yale und Dr.H. Brintzinger, Basel, danke ich für wertvolle Diskussionen und Hinweise.

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Hemmerich, P. Über das Verhalten von Riboflavin-Semichinon gegen Metallionen. Modellstudien zur Metall-Flavoenzymkatalyse. Experientia 16, 534–535 (1960). https://doi.org/10.1007/BF02158439

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