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The fate of 4-hydroxytryptophan in the rat organism

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Riassunto

Nell'organismo del ratto ha luogo una rapida ed intensa decarbossilazione del 4-idrossitriptofano a 4-idrossitriptamina. Oltre ad essere attaccata dalla monoaminossidasi, con formazione di acido 4-idrossiindolacetico, l'amina viene anche O-coniugata con acido glucuronico. Analogamente al 5-idrossitriptofano, anche il 4-idrossitriptofano valica la barriera ematoencefalica dando luogo a formazione di 4-idrossitriptamina nella compagine del tessuto nervoso.

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References

  1. V. Erspamer, A. Glässer, C. Pasini, andG. Stoppani, Nature, in press.

  2. Sold by Hopkin & Williams Ltd., Chadwell Heath (Essex, England).

  3. V. Erspamer, A. Glässer, andP. Mantegazzini, Exper.16, 505 (1960).

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Authors and Affiliations

  1. Istituto di Farmacologia, Università di Parma, Italy

    V. Erspamer, A. Glässer, B. M. Nobili & C. Pasini

Authors
  1. V. Erspamer
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  2. A. Glässer
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  3. B. M. Nobili
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  4. C. Pasini
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Additional information

A full report on the methods used in this study, as well as on the biochemical and pharmacological results will be published elsewhere, together with the discussion of the collected data.

Supported by a grant from the Rockefeller Foundation, New York.

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Erspamer, V., Glässer, A., Nobili, B.M. et al. The fate of 4-hydroxytryptophan in the rat organism. Experientia 16, 506–507 (1960). https://doi.org/10.1007/BF02158368

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  • DOI: https://doi.org/10.1007/BF02158368

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