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Strukturabhängigkeit der Wirkung muscarinähnlicher Verbindungen

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Summary

Relations between structure and biological activity of some new analogues of muscarine are demonstrated. From the results a theory of cholinergic action and the structure of active acetylcholine, as well as the cholinergic receptor, may be developed.

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References

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  3. Die Verbindungen I–V, IX, XII–XV wurden vonE. Hardegger et al., Eidgenössische Technische Hochschule Zürich, VI und VII vonF. Häfliger undR. Denss, J. R. Geigy AG., Basel, VIII, X und XI vonC. H. Eugster undK. Allner, Universität Zürich, synthetisiert und uns in verdankenswerter Weise zur Verfügung gestellt. Alle Stoffe sind Jodsalze der Racemate, ausser denD- undL-Antipoden des Muscarins und Muscarons. Die Stereostruktur der Verbindungen III und XII ist noch nicht gesichert.

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  5. R. B. Barlow,Introduction to Chemical Pharmacology (Methuen, London 1955), p. 127.

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  6. P.G. Waser,Chemistry and Pharmacology of Muscarine, Muscarone and some Related Compounds, Pharmacological Reviews, in Vorbereitung.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Zürich, Schweiz

    P. Waser

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  1. P. Waser
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Waser, P. Strukturabhängigkeit der Wirkung muscarinähnlicher Verbindungen. Experientia 17, 300–302 (1961). https://doi.org/10.1007/BF02158163

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  • DOI: https://doi.org/10.1007/BF02158163

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