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Connective tissue reactions in experimentally induced hypertension

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Zusammenfassung

Histologische Untersuchungen verschiedener Gefässgebiete von renal hypertonischen Ratten zeigten keine Abhängigkeit der Gefäßschäden vom Verlauf des Hochdruckes. Typische Gefässveränderungen für den experimentellen Hochdruck sind auch bei solchen Tieren zu finden, deren systolischer Druck trotz Einengen einer Nierenarterie nicht signifikant anstieg. Die Bindegewebsreaktion gegenüber einem Fremdkörper wird gesteigert. Es wird unterschieden zwischen Faktoren, die für die Hochdruckentstehung, und solchen, die für eine Umstimmung des Mesenchyms verantwortlich sind. Beide Prozesse können methodisch gleichartig ausgelöst werden. Es sind sexualspezifische Unterschiede vorhanden, da im allgemeinen Weibchen zu einer verstärkten Blutdruckreaktion, Männchen dagegen zu vermehrten Gefäßschädigungen neigen, besonders zu sklerotischen Veränderungen. Bei Klammerung einer Nierenarterie führt die gleichzeitige Exstirpation der zweiten Niere zu einer Änderung des Hochdrucks in qualitativer Hinsicht.

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Authors and Affiliations

  1. Research Laboratories of the Pharmaceutical Department of CIBA Limited, Basle

    P. Loustalot

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  1. H. J. Bein
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  2. P. A. Desaulles
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  3. P. Loustalot
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Dedicated to ProfessorRolf Meier on the occasion of his 60th birthday.

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Bein, H.J., Desaulles, P.A. & Loustalot, P. Connective tissue reactions in experimentally induced hypertension. Experientia 13, 130–135 (1957). https://doi.org/10.1007/BF02157577

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