Die Wirkung von Desoxycorticosteron auf den aktiven Kationenaustausch an Rattenblutzellen

Summary

Cold-stored blood cells of rats, which were depleted of potassium and had gained an equivalent amount of sodium instead, were incubated with 500 mg% glucose at 37°C in serum. Under these conditions an extrusion of sodium from and a re-entry of potassium into the cells could be observed. Desoxycorticosterone, when added in a concentration of 1 mg per ml, was able to slow down the rate of this exchange to three fifths of the rate of untreated cells. With blood of adrenalectomised rats, the same effect of DOC was observed, although the rate without DOC was somewhat lower than in the blood of normal animals. There was no statistically significant difference between the DOC-effect in blood of normal and adrenalectomised rats.