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In vitro guanidino-resistance and guanidino-dependence of poliovirus

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Riassunto

Il virus poliomielitico può essere reso,in vitro, guanidino-resistente se propagato serialmente in culture cellulari contenenti dosi crescenti di guanidina. Proseguendo nei passaggi seriali in presenza delle dosi massime di guanidina tollerate dalle cellule, si ottiene un ceppo di polio virus che si sviluppa assai meglio in terreni contenenti la sostanza che non in terreni che ne siano privi.

Tale caratteristica, che richiama quella della antibiotico-dipendenza di alcuni schizomiceti, sembra deporre per una autonomia del virus rispetto alla cellula ospite maggiore di quanto sinora ritenuto.

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Authors and Affiliations

  1. Istituto di Farmacologia, Igiene e Microbiologia dell'Università di Cagliari, Italy

    B. Loddo, W. Ferrari, A. Spanedda & G. Brotzu

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  1. B. Loddo
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  2. W. Ferrari
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  3. A. Spanedda
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  4. G. Brotzu
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Loddo, B., Ferrari, W., Spanedda, A. et al. In vitro guanidino-resistance and guanidino-dependence of poliovirus. Experientia 18, 518–519 (1962). https://doi.org/10.1007/BF02151608

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