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Synthetic activators of fibrinolysis which possess anticoagulant property

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Zusammenfassung

Derivate von Salicylsäure aktivieren im Reagenzglas das fibrinolytische System des menschlichen Plasmas und üben eine gerinnungshemmende Wirkung aus. Durch planmässige Veränderungen der Substituenten des Salicylsäuremoleküls gelang es, in zunehmendem Masse Verbindungen mit steigender fibrinolytischer Aktivität aufzufinden. Die gerinnungshemmende und fibrinolytische Wirkung wird am Beispiel derortho-Thymotinsäure erläutert.

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References

  1. K. N. von Kaulla,Chemistry of Thrombolysis: Human Fibrinolytic Enzymes (C. C. Thomas Publisher, Springfield 1963).

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  6. These compounds were kindly provided by Dr.J. M. Sprague, Merck Sharp & Dohme Research Laboratories, West Point (Pa. USA).

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Authors and Affiliations

  1. Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA

    K. N. von Kaulla

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  1. K. N. von Kaulla
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von Kaulla, K.N. Synthetic activators of fibrinolysis which possess anticoagulant property. Experientia 21, 439–440 (1965). https://doi.org/10.1007/BF02150803

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