Abstract
In a retrospective histopathological study of 75 eyes with occlusive retinal vascular disease, intraretinal, preretinal and prepapillary neovascularisation was observed in 76%, 48% and 48%, respectively. The central retinal vein, artery and branch arteries were shown to be occluded in 48, 46 and 6 cases, respectively. Generalised obliterative arteriolovenular sclerosis was observed on 24 occasions; combined stem occlusions of the central retinal vein and artery was found in 33 specimens.
A most significant finding was the presence of intramural capillaries within hyalinised retinal vessels in 51 cases (68%). These newly formed capillaries originated from proliferating vascular endothelium; their lumina communicated with the vascular lumen and continued in many instances into congeries of newly formed intra- and preretinal capillaries. The diseased parent vessels showed evidence of plasmatic insudation and transudation (100%) and endothelial proliferation (97%). These phenomena constitute the first stage of a type of retinal neovascularisation which has not hitherto been adequately described.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ashton N (1967) Oxygen and the growth and development of retinal vessels. In: Kimura SJ, Caygill WM (eds) Vascular complications of diabetes mellitus. CV Mosby Co, St. Louis, pp 3–32
Blumenthal HT, Cowdry HV (1967) Functional anatomy of the vascular system. In: Blumenthal HT (ed) Cowdry's arteriosclerosis. A survey of the problem, 2nd edn. Charles C Thomas, Springfield, Illinois, pp 47–65
Coats G (1904) Thrombosis of the central retinal vein of the retina. Ophthalmol Hosp Rep 16: 62–122
Coats G (1913) Der Verschluß der Zentralvene der Retina. Graefe's Arch Clin Exp Ophthalmol 86: 341–393
Folkman J, Haudenschild C (1980a) Angiogenesis in vitro. Nature 288: 551–556
Folkman J, Haudenschild C (1980b) Angiogenesis by capillary endothelial cells in culture. Trans Ophthalmol Soc UK 100: 346–353
Folkow B, Neil E (1971) Circulation. Oxford University Press, New York, p 18
Geiringer E (1951) Intimal vascularization and atherosclerosis. J Pathol Bacteriol 63: 201–211
Green WR, Chan CC, Hutchins GM, Terry JM (1981) Central retinal vein occlusion: A prospective histopathologic study of 29 eyes in 28 cases. Retina 1: 27–55
Henkind P (1978) Ocular neovascularization. Am J Ophthalmol 85: 287–301
LeCompte PM (1967) Reactions of the vasa vasorum in vascular disease. In: Blumenthal HT (ed) Cowdry's arteriosclerosis. A survey of the problem, 2nd edn. Charles C Thomas, Springfield, Illinois, pp 212–224
Leishman R (1957) The eye in general vascular disease — hypertension and arteriosclerosis. Br J Ophthalmol 41: 641–701
Lendrum AC (1963) The hypertensive diabetic kidney as a model of the so-called collagen diseases. Can Med Assoc J 88: 442–452
Loewenstein A (1946) Retinal vascular changes studied in bulk. Trans Ophthalmol Soc UK 66: 581–593
Loewenstein A (1948) Intramural vascular system (vasa vasorum?) in retinal vessels. Arch Ophthalmol 39: 9–26
Manschot WA (1954) Etiology of retrolental fibroplasia. Arch Ophthalmol 52: 833–845
Meyer WW (1949) Die Bedeutung der Eiweißablagerungen in der Histogenese arteriosklerotischer Intimaveränderungen der Aorta. Virchow's Arch Pathol Anat Physiol 316: 268–316
Seitz R (1964) The retinal vessels. CV Mosby Co, St. Louis, pp 79–101
Verhoeff FH (1907) Obstruction of the central retinal vein. Arch Ophthalmol 36: 1–36
Winternitz MC (1954) The blood supply of the vessel wall. In: Symposium on atherosclerosis. Natl Acad Sci, Washington, Publ 338: 14–23
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Manschot, W.A., Lee, W.R. Retinal neovascularisation arising from hyalinised blood vessels. Graefe's Arch Clin Exp Ophthalmol 222, 63–70 (1984). https://doi.org/10.1007/BF02150633
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02150633