Abstract
Eighty-four rabbit eyes injected intravitreously with tissue-cultured fibroblasts following gas compression of the vitreous were examined clinically over a period of 1 month. Detailed clinical descriptions of the extent of retinal changes were recorded. Clinical landmarks were determined and arranged into a new classification of this model of proliferative vitreoretinopathy (PVR). The proposed classification will allow easier communication between research groups using this model to study the treatment and prevention of PVR.
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Algvere P, Kock E (1976) Experimental fibroplasia in rabbit vitreous. Retinal detachment induced by autologous fibroblasts. Graefe's Arch Clin Exp Ophthalmol 199: 215–222
Blumenkranz MS, Ophir A, Claflin AJ, Kajek A (1982) Fluorouracil for the treatment of massive preretinal proliferation. Am J Ophthalmol 94: 458–467
Chandler DB, Rozakis G, de Juan E Jr, Machemer R (1985) The effect of triamcinolone acetonide on a refined experimental model of proliferative vitreoretinopathy. Am J Ophthalmol 99: 686–690
Chandler DB, Quansah FA, Hida T, Machemer R (1986) A refined experimental model for proliferative vitreoretinopathy. Graefe's Arch Clin Exp Ophthalmol 224: 86–91
Chandler DB, Hida T, Rozakis G, Machemer R (1987) The effects of steroids on cell contraction in experimental proliferative ultreoretinopathy. Invest, Ophthalmol [Suppl] 28: 207
Fastenberg DM, Diddie KR, Dorey K, Ryan SJ (1982) The role of cellular proliferation in an experimental model of massive periretinal proliferation. Am J Ophthalmol 93: 565–572
Hsu HT, Dorey K, Sorgente N, Ryan SJ (1984) Surgical removal of vitreous. Its effect on intraocular fibroblast proliferation in the rabbit. Arch Ophthalmol 102: 605–607
Miller B, Lean JS, Miller H, Ryan SJ (1984) Intravitreal expanding gas bubble: a morphologic study in the rabbit eye. Arch Ophthalmol 102: 1708–1711
Stern WH, Fisher SK, Anderson DH, O'Donnell JJ, Erickson PA, Lewis GP, Guerin CJ, Borgula GA, McDermott MA (1982) Epiretinal membrane formation after vitrectomy. Am J Ophthalmol 93: 757–772
Sugita G, Tano Y, Machemer R, Abrams G, Claflin A, Fiorentino G (1980) Intravitreal autotransplantation of fibroblasts. Am J Ophthalmol 89: 121–130
Tano Y, Sugita G, Abrams G, Machemer R (1980) Inhibition of intraocular proliferations with intravitreal corticosteroids. Am J Ophthalmol 89: 131–136
Tano Y, Chandler DB, Machemer R (1981) Retinal neovascularization after intravitreal fibroblast injection. Am J Ophthalmol 92: 103–109
Thresher RJ, Ehrenberg M, Machemer R (1984) Gas-mediated vitreous compression: an experimental alternative to mechanized vitrectomy. Graefe's Arch Clin Exp Ophthalmol 221: 192–198
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Supported by the National Eye Institute, Grants EYO2903 and P30 EYO5722, Research to Prevent Blindness, Inc., and Alcon Laboratories, Fort Worth, Texas
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Hida, T., Chandler, D.B. & Sheta, S.M. Classification of the stages of proliferative vitreoretinopathy in a refined experimental model in the rabbit eye. Graefe's Arch Clin Exp Ophthalmol 225, 303–307 (1987). https://doi.org/10.1007/BF02150154
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DOI: https://doi.org/10.1007/BF02150154