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Relationship between the structure of chloramphenicol and its action upon peptide synthetase

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Zusammenfassung

Zusammenhänge zwischen Struktur und Wirkung bei Chloramphenicol führen zu der Hypothese, dass das Antibiotikum die Peptidsynthetase der Ribosome dadurch hemmt, dass es den Peptidylpartner der Reaktion antagonisiert. Im Einklang damit steht, dass Chloramphenicol sich spezifisch an Ribosome bindet und selektiv die Elongationsphase der Proteinsynthese hemmt.

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  1. Department of Molecular Biology, Walter Reed Army Institute of Research, 20012, Washington D.C., USA

    F. E. Hahn

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  1. F. E. Hahn
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Hahn, F.E. Relationship between the structure of chloramphenicol and its action upon peptide synthetase. Experientia 24, 856–858 (1968). https://doi.org/10.1007/BF02144918

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