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Large bowel tumors and diamine oxidase (DAO) activity in patients: A new approach for risk group identification

  • Histamine in Pathophysiology and Clinical Studies
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Abstract

In the intestinal mucosa, diamine oxidase (DAO) seems to be involved in a feed-back regulation mechanism for the termination of proliferation. Therefore, we studied the DAO activity in large bowel tumors and in the non-affected mucosa of these patients in comparison with patients having a normal large mucosa. The DAO activity in the tumor tissue itself was diminished by 85% as compared to the surrounding mucosa. Comparing the colonic mucosa of normal and tumor bearing indivaduals, the DAO activity in cancer patients was diminished by 22%, while it was elevated by 64% in patients with polyps (biphasic response of the DAO activity). Histologically proven hyperproliferative mucosal alterations were indicated by a reduced DAO activity with 75% sensitivity and 42% specificity. It remains open whether this limited specificity may indicate a more sensitive reaction of the DAO activity to proliferative mucosal alterations than the histological examinations.

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Authors and Affiliations

  1. IInd. Dept. of Surgery of the University of Cologne, Ostmerheimerstraße 200, D-5000, Köln 91, FRG

    R. Mennigen & H. Sommer

  2. Biochemical & Experimental Division of the IInd. Dept. of Surgery of the University of Cologne, Ostmerheimerstraße 200, D-5000, Köln 91, FRG

    J. Kusche, A. Elbers, B. Amoei & M. Kessebohm

  3. Medical Clinic I, Cologne, Merheim, Ostmerheiserstraße 200, D-5000, Köln 91, FRG

    B. Krakamp

Authors
  1. R. Mennigen
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  2. J. Kusche
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  3. B. Krakamp
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  4. A. Elbers
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  5. B. Amoei
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  6. M. Kessebohm
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  7. H. Sommer
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Supported by a grant of the Deutsche Forschungsgemeinschaft Ku 464/2-3.

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Mennigen, R., Kusche, J., Krakamp, B. et al. Large bowel tumors and diamine oxidase (DAO) activity in patients: A new approach for risk group identification. Agents and Actions 23, 351–353 (1988). https://doi.org/10.1007/BF02142585

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  • DOI: https://doi.org/10.1007/BF02142585

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