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Thymoxamine: A miotic for intraocular use

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Abstract

Thymoxamine hydrochloride can be used intraocularly to reverse phenylephrine or epinephrine mydriasis during intraocular surgery (0.2–0.5 ml of 0.01% or 0.02% solutions proved to be effective). No endothelial damage was found up to a dose of 1 ml of 0.02% thymoxamine in animal experiments using a physiologically buffered solution. Since stability is low in the buffered state, the final concentration has to be prepared at the time of surgery using a 0.5% solution and a phosphate buffer. Intracameral thymoxamine is a potent miotic during operations and can be helpful in extracapsular cataract surgery, keratoplasty, and repair of perforating injuries.

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Authors and Affiliations

  1. Department of Ophthalmology, University Hospitals, Freiburg i.Br., Federal Republic of Germany

    F. Grehn & T. Fleig

  2. Hospital Pharmacy of the, University Hospitals, Freiburg i.Br., Federal Republic of Germany

    E. Schwarzmüller

Authors
  1. F. Grehn
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  2. T. Fleig
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  3. E. Schwarzmüller
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Grehn, F., Fleig, T. & Schwarzmüller, E. Thymoxamine: A miotic for intraocular use. Graefe's Arch Clin Exp Ophthalmol 224, 174–178 (1986). https://doi.org/10.1007/BF02141493

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  • DOI: https://doi.org/10.1007/BF02141493

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