Summary
The biosynthesis of reserpinine (II) and vincamedine (IVa) in Vinca plants has been investigated with the help of labelled precursors. Incorporation of 1-14C-Sodium acetate into the non-tryptophan C10-moiety of these alkaloids occurred only with extensive randomization of the label. In addition, indications were obtained that the methyl group of methionin is not involved in the formation of this fragment.
Literatur
Für eine zusammenfassende Darstellung vgl.E. Leete inP. Bernfeld,Biogenesis of Natural Compounds (Pergamon Press, 1963), p. 768: fernerA. R. Battersby,Biogenesi delle Sostanze Naturali (Accademia Nazionale dei Lincei, Roma 1964), p. 47.
P. N. Edwards undE. Leete, Chem. Ind.1961, 1666.
E. Leete undS. Ghosal, Tetrahedron Lett.1962, 1179.
E. Leete, S. Ghosal undP. N. Edwards, J. Am. chem. Soc.84, 1068 (1962).
A. R. Battersby, R. Binks, W. Lawrie, G. V. Parry undB. R. Webster, Proc. chem. Soc.1963, 369.
M. Hesse,Indolalkaloide in Tabellen (Springer Verlag, 1964).
D. H. R. Barton, R. H. Hesse undG. W. Kirby, Proc. chem. Soc., 267 (1963).
A. R. Battersby, R. J. Francis, M. Hirst undJ. Staunton, Proc. chem. Soc.1963, 268.
R. N. Gupta undI. D. Spencer, Biochem. biophys. Res. Commun.13, 115 (1963).
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Goeggel, H., Arigoni, D. Zur Biosynthese von Reserpinin und Vincamedin. Experientia 21, 369–370 (1965). https://doi.org/10.1007/BF02139738
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DOI: https://doi.org/10.1007/BF02139738