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Antimalarial activity of natural, racemic and unnatural dihydroquinine, dihydroquinidine and their various racemic analogs in mice infected withPlasmodium berghei

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  • Biologica, Microbiologica
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Zusammenfassung

Racemisches Dihydrochinin und die beiden optischen Antipoden zeigen die gleiche Aktivität gegenPlasmodium berghei wie Chinin. Hingegen waren die entsprechenden Dihydrochinidine sowie die 6′-Desmethoxy-7′-chlor-Analogen von Dihydrochinin und Dihydrochinidin etwa viermal wirksamer.

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Literatur

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  3. M. Gates, B. Sugavanam andW. L. Schreiber, J. Am. chem. Soc.92, 205 (1970).

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  4. The unnatural enantiomers of dihydroquinine and dihydroquinidine were first prepared byP. Rabe andA. Schultze, Ber. dt. chem. Ges.66, 120 (1933), but results on their antimalarial activity are not available.

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  5. The racemates of dihydroquinine and dihydroquinidine were first prepared byP. Rabe, W. Huntenberg, A. Schultze andG. Volger, Ber. dt. chem. Ges.64, 2487 (1931); the antimalarial activity of racemates are also not reported.

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  6. Determination of LD50 was performed by Dr.W. Pool, Department of Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey, USA.

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Authors and Affiliations

  1. Chemical Research Division, Hoffmann-La Roche Inc., 07110, Nutley, New Jersey, USA

    A. Brossi, M. Uskoković, J. Gutzwiller, Antoniana U. Krettli & Z. Brener

  2. Instituto Nacional de Endemias Rurais, C.P. 1743

    A. Brossi, M. Uskoković, J. Gutzwiller, Antoniana U. Krettli & Z. Brener

  3. Department of Parasitology, University of Minas Gerais, Belo Horizonte, Brazil

    A. Brossi, M. Uskoković, J. Gutzwiller, Antoniana U. Krettli & Z. Brener

Authors
  1. A. Brossi
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  2. M. Uskoković
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  3. J. Gutzwiller
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  4. Antoniana U. Krettli
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  5. Z. Brener
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Brossi, A., Uskoković, M., Gutzwiller, J. et al. Antimalarial activity of natural, racemic and unnatural dihydroquinine, dihydroquinidine and their various racemic analogs in mice infected withPlasmodium berghei . Experientia 27, 1100–1101 (1971). https://doi.org/10.1007/BF02138906

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  • DOI: https://doi.org/10.1007/BF02138906

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