Zusammenfassung
Das Bradykinin-potenzierende Peptid B (Pyr-Gly-Leu-Pro-Pro-Arg-Pro-Lys-Ile-Pro-Pro) verhindert in vitro und in vivo die Aktivität der Plasmakininase und des «converting»-Enzyms.
Literatur
S. H. Ferreira andM. Rocha e Silva, Biochem. Pharmac.11, 1123 (1962).
A. J. Osbahr, J. A. Gladner andK. Laki, Biochim. biophys. Acta86, 535 (1964).
J. A. Gladner, P. A. Murtaugh, J. E. Folk andK. Laki, Ann. N.Y. Acad. Sci.104, 47 (1963).
P. N. Aarsen, Br. J. Pharmac.32, 453 (1968).
U. Hamberg, P. Ely andP. Stelwagen,Pharmacology of Hormonal Polypeptides and Proteins (Plenum Press, New York 1968), p. 626.
K. Buluk andM. Malofiejew, Br. J. Pharmac.35, 79 (1969).
S. H. Ferreira, Br. J. Pharmac.24, 163 (1965).
S. H. Ferreira, L. J. Greene, V. A. Alabaster, Y. S. Bakhle andJ. R. Vane, Nature225, 379 (1970).
J. W. Alken andJ. R. Vane, Nature, Lond.228, 30 (1970).
J. M. Stewart, S. H. Ferreira andL. J. Greene, Biochem. Pharmac., in press (1971).
H. Kato andT. Suzuki, Proc. Japan Acad.46, 176 (1970).
H. Kato andT. Suzuki, Experientia26, 1205 (1970).
E. Ueda, H. Akutsu, T. Kokubu andY. Yamamura, Jap. Circulation J., in press (1971).
P. T. Pickens, F. M. Bumpus, A. M. Lloyd, R. R. Smeby andL. H. Page, Circulation Res.17, 438 (1965).
Author information
Authors and Affiliations
Additional information
Acknowledgment. The authors wish to thank Dr. H.Kato of Institute for Protein Research, Osaka University, for his kind supply of BPP. Thanks also Dr. S.Sakakibara of Institute for Protein Research, Osaka University, for his kind supply of synthetic angiotensin I and bradykinin.
Rights and permissions
About this article
Cite this article
Ueda, E., Kokubu, T., Akutsu, H. et al. Inhibition of angiotensin I converting enzyme and kininase in rabbit plasma by bradykinin potentiating peptide B (Pyr-Gly-Leu-Pro-Arg-Pro-Lys-Ile-Pro-Pro). Experientia 27, 1020–1021 (1971). https://doi.org/10.1007/BF02138854
Issue Date:
DOI: https://doi.org/10.1007/BF02138854