Skip to main content
SpringerLink
Log in

Relationship between teratogeny and structure in the thalidomide field

  • Specialia
  • Chimica. Biochimica. Biophysica
  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

Thalidomid verursacht an trächtigen Neuseeland-Kaninchen nach oraler Verabreichung starke Missbildungen des Wurfes. Geringe strukturelle Abweichungen können die Teratogenie zerstören: Zwei solche Verbindungen,N-Methoxy-thalidomid und 2-Phthalimido-glutaramid, sind nicht teratogen, während ein Esteramid, ein Thalidomidanalog mit offener Kette, hauptsächlich Missbildungen der inneren Organe erzeugt.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. H. M. Wuest, E. B. Sigg andI. Fratta, Life Sci.3, 721 (1964).

    Article  CAS  Google Scholar 

  2. H. M. Wuest, I. Fratta andE. B. Sigg, Life Sci.5, 393 (1966).

    Article  CAS  Google Scholar 

  3. S. Fabro, H. Schuhmacher, R. L. Smith, R. B. L. Stagg andR. T. Williams, Biochem. J.90, 5 (1964).

    Article  Google Scholar 

  4. H. Keberle, P. Loustalot, R. K. Maller, J. W. Faigle andK. Schmid, Ann. N.Y. Acad. Sci.123, 252 (1965).

    Article  CAS  Google Scholar 

  5. H. Fritz, J. Reprod. Fert.11, 157 (1966).

    Article  Google Scholar 

  6. J. W. Faigle, H. Keberle, W. Riess andK. Schmid, Experientia18, 389 (1962).

    Article  CAS  Google Scholar 

  7. R. T. Williams andD. V. Parke, A. Rev. Pharmac.4, 91 (1964).

    Google Scholar 

  8. J. C. Sheehan andW. A. Bolhofer, J. Am. chem. Soc.72, 2472 (1950).

    Article  CAS  Google Scholar 

  9. P. B. Sawin, D. D. Crary, R. R. Fox andH. M. Wuest, Experientia21, 672 (1965).

    Article  CAS  Google Scholar 

  10. A. E. Suitor, USDA Leaflet 245 (1946).

Download references

Author information

Authors and Affiliations

  1. Sloan-Kettering Institute for Cancer Research, 10021, New York City, N.Y.

    H. M. Wuest, R. R. Fox & D. D. Crary

  2. The Jackson Laboratory, Bar Harbor, Maine, USA

    H. M. Wuest, R. R. Fox & D. D. Crary

Authors
  1. H. M. Wuest
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. R. Fox
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. D. Crary
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This research was supported in part by Public Health Service Research Grants, no. HD-01496 from the National Institute of Child Health and Human Development and No. FR-00251 from the Division of Research Facilities and Resources to The Jackson Laboratory, Bar Harbor, Maine; and Public health Service Grant No. CA-08748 to The Sloan-Kettering Institute for Cancer Research.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wuest, H.M., Fox, R.R. & Crary, D.D. Relationship between teratogeny and structure in the thalidomide field. Experientia 24, 993–994 (1968). https://doi.org/10.1007/BF02138700

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02138700

Keywords

Search

Navigation