Zusammenfassung
Eine neue Methode zur Entfernung der Schutzgruppe von NG-Tos-Arg mittels wasserfreier Flußsäure und ihre Anwendung für die Synthese von Bradykinin wird beschrieben.
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References
E. Schröder andK. Lübke,The Peptides (Academic Press, New York, London 1965), vol. 1, p. 167.
S. Sakakibara, Y. Shimonishi, Y. Kishida, M. Okada andH. Sugihara, Bull. chem. Soc. Japan40, 2164 (1967). These authors reported the tosyl group to be stable in liquid HF at 20°.
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Hydrogenation:W. M. Selby.
R. H. Mazur, B. W. Ellis andP. S. Cammarata, J. biol. Chem.237, 1619 (1962).
Elemental analyses:E. Zielinski.
Amino acid analyses:J. W. Ahlberg.
Bioassays:J. H. Sanner. The effect on guinea-pig ileum was compared with standard bradykinin (Sandoz Pharmaceuticals, Hanover, New Jersey, BRS-640, Lot 64003).
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Mazur, R.H., Plume, G. Improved synthesis of bradykinin. Experientia 24, 661 (1968). https://doi.org/10.1007/BF02138296
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DOI: https://doi.org/10.1007/BF02138296