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1-(5-Methyl-1-phenyl-4-pyrazolyl)-3-[4-(o-tolyl)-piperazinyl]-1-propanone, a new synthetic antihypertensive agent

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  • Chimica. Biochimica
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Zusammenfassung

1-(5-Methyl-1-phenyl-4-pyrazolyl)-3-[4-(o-tolyl)-piperazinyl]-1-propanone (I; CIBA 1002-Go), senkt an normotonischen und hypertonischen Tieren den Blutdruck. Die Drucksenkung kann auf eine periphere Vasodilatation und eine Hemmung hypothalamischer oder medullärer Vasomotorenzentren bezogen werden. Ausserdem wirkt CIBA 1002-Go adrenolytisch.

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References

  1. V. P. Arya, inCNS Drugs (Council of Scientific and Industrial Research, New Delhi 1966), p. 35.

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Authors and Affiliations

  1. CIBA Research Centre, Goregaon East, Bombay 63, India

    V. P. Arya, R. S. Grewal, J. David & C. L. Kaul

Authors
  1. V. P. Arya
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  2. R. S. Grewal
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  3. J. David
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  4. C. L. Kaul
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Additional information

Hydrochloride = CIBA 1002-Go.

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Arya, V.P., Grewal, R.S., David, J. et al. 1-(5-Methyl-1-phenyl-4-pyrazolyl)-3-[4-(o-tolyl)-piperazinyl]-1-propanone, a new synthetic antihypertensive agent. Experientia 23, 514–515 (1967). https://doi.org/10.1007/BF02137938

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  • DOI: https://doi.org/10.1007/BF02137938

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