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Plasma angiotensin, serum ‘angiotensinase activity’, and blood pressure response during angiotensin II amide infusions in normal volunteers

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Résumé

Des doses croissantes d'angiotensine II amide furent injectées à des volontaires normaux. La réponse de la pression artérielle fut en relation directe avec le log de la dose de peptide injectée, avec la concentration sérique en sodium et avec l'activité sérique «angiotensinase», mais en relation inverse avec l'augmentation de la concentration plasmatique en angiotensine. Ces résultats suggèrent que la réponse de pression est déterminée, au moins en partie, par le «turnover» du peptide au niveau des récepteurs et qu'à ce niveau angiotensinase influence le «turnover» et la concentration plasmatique du peptide.

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Authors and Affiliations

  1. Department of Medicine, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA

    G. D. Lubash, G. E. Muiesan, C. L. Alicandri, D. J. Garfinkel, E. C. Siekierski & C. K. McConnaughey

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  1. G. D. Lubash
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  2. G. E. Muiesan
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  3. C. L. Alicandri
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  4. D. J. Garfinkel
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  5. E. C. Siekierski
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  6. C. K. McConnaughey
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Additional information

Supported by U.S.P.H.S. Grant No. HE 11691-02, NIH; the American and Maryland Heart Associations; and the Kidney Foundation of Maryland. Thanks are due Dr.J. R. Hebel for statistical analyses and MissD. S. Baker for secretarial assistance.

Supported by the Fulbright-Hays Program and the Italian National Research Council.

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Lubash, G.D., Muiesan, G.E., Alicandri, C.L. et al. Plasma angiotensin, serum ‘angiotensinase activity’, and blood pressure response during angiotensin II amide infusions in normal volunteers. Experientia 27, 68–69 (1971). https://doi.org/10.1007/BF02137747

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  • DOI: https://doi.org/10.1007/BF02137747

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