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Binding of 5-hydroxytryptamine and noradrenaline by rat lung

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  • Pharmacologica
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Résumé

Après injection i.v. de 5-hydroxatryptamine-C14 et de noradrénaline-H3 à des rats, on a préparé et centrifugé des homogénates de leurs poumons dans un gradient linéaire de sucrose. Après sacrifice immédiat ces deux amines sont retrouvées dans une grande fraction de particules pulmonaires sédimentant dans 1M de sucrose. Après 30 min les poumons des rat offrent un pic additionel de noradrénaline-H3 correspondant à une densité de sucrose de 0.4 à 0.5.

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Literatur

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Authors and Affiliations

  1. Departments of Anesthesiology and Pharmacology, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, Connecticut, USA

    C. N. Gillis

Authors
  1. C. N. Gillis
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Additional information

This work was supported in part by Grant No. 13315 from the U.S. Public Health Service and by Grant No. 435 from the Connecticut Heart Association. Assistance provided by Ayerst Laboratories and Astra Laboratories is also gratefully acknowledged.

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Gillis, C.N. Binding of 5-hydroxytryptamine and noradrenaline by rat lung. Experientia 27, 1317–1319 (1971). https://doi.org/10.1007/BF02136712

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  • DOI: https://doi.org/10.1007/BF02136712

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