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Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes

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  • Experimental Oncology
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Summary

Diastereomeric para-substituted dichloro-(1,2-diphenylethylenediamine)platinum(II) complexes were synthesized and tested for their antitumor activity on the human MDA-MB 231 breast cancer cell line and the P 388 leukemia of the mouse. An interaction with the DNA was demonstrated by UV difference spectroscopy. The D,L configurated, 4-fluoro-substituted complex was the most active.

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Authors and Affiliations

  1. Institut für Pharmazie, Lehrstuhl Pharmazeutische Chemie II, Sonderforschungsbereich 234, Universitätsstrasse 31, D-8400, Regensburg, Germany

    Margaretha Jennerwein, Beate Wappes, Ronald Gust & Helmut Schönenberge

  2. Forschung-Degussa Pharma Gruppe, Daimlerstrasse 25, D-6000, Frankfurt 1, Germany

    Jürgen Engel

  3. Städt. Krankenhaus Leverkusen, Zentrum Innere Medizin, Medizinische Klinik III, Dhünnberg 60, D-5090, Leverkusen 1, Germany

    Siegfried Seeber

  4. Innere Universitätsklinik und Poliklinik (Tumorforschung), Westdeutsches Tumorzentrum, Hufelandstrasse 55, D-4300, Essen, Germany

    Reinhardt Osieka

Authors
  1. Margaretha Jennerwein
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  2. Beate Wappes
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  3. Ronald Gust
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  4. Helmut Schönenberge
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  5. Jürgen Engel
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  6. Siegfried Seeber
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  7. Reinhardt Osieka
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Jennerwein, M., Wappes, B., Gust, R. et al. Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. J Cancer Res Clin Oncol 114, 347–358 (1988). https://doi.org/10.1007/BF02128177

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  • DOI: https://doi.org/10.1007/BF02128177

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