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Natural occurrence of mycotoxins in cereals

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Abstract

Besides peanuts and cottonseed, cereal grains are the most important feed and food source that occasionally are naturally contaminated with mycotoxins. The problem of mycotoxins occurring naturally in cereals, especially in corn, has become trouble-some because of changing agricultural technology. The mycotoxin problem in cereals is not restricted to any geographic or climatic region. Toxins are produced on cereals, both in the field and in storage; they involve both the grain and the whole plant. The genera of fungi most involved areAspergillus, Fusarium, Penicillium andClaviceps. Mycotoxins known to occur naturally in cereals include aflatoxins B1, B2, G1 and G2-as well as aflatoxins M1 and M2-ochratoxins A and B, penicillic acid, patulin, ergot, zearalenone, citrinin, T-2, tenuazonic acid, kojic acid and sterigmatocystin. Of these mycotoxins, aflatoxins, patulin, penicillic acid and sterigmatocystin are carcinogens.

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References

  • Alpert, M. E., M. S. R. Hutt, G. N. Wogan & C. S. Davidson (1971) Association between aflatoxin content of food and hepatoma frequency in Uganda. Cancer 28: 253–260.

    PubMed  Google Scholar 

  • Anonymous (1965) Report of the Tropical Products Institute, 1964, VI+36 pp. London, H. M. Stationery Office.

  • Anonymous (1969a) FDA Pap. 3: 33.

  • Anonymous (1969b) FDA Pap. 3: 31.

  • Anonymous (1970) FDA Pap. 4: 41.

  • Anonymous (1972) FDA Pap. 6: 29.

  • Anonymous (1973) FDA Consumer 7: 32.

    Google Scholar 

  • Austwick, P. K. C., P. Krogh, L. P. Smith & J. L. Longbottom (1972) A preliminary mycological investigation of endemic nephropathy in Yugoslavia. In preparation.

  • Bamburg J. R. (1972) The biological activities and detection of naturally occurring 12, 13-epoxy-Δ9-trichothecenes. Clin. Toxicol. 5: 495–515.

    PubMed  Google Scholar 

  • Bubien, Z., B. Mikolajczak & M. Bohosiewicz (1968) Studies on aflatoxin content in groundut cakes and grinding grains. Zesz. Nauk. Wyzsz. Szk. Roln. Wrocl. 78: 203–214.

    Google Scholar 

  • Campbell, T. C. & L. Salamat (1971) Aflatoxin ingestion and excretion by humans. In I. F. H. Purchase (ed.), ‘Symposium on Mycotoxins in Human Health’, pp. 271–280.

  • Ciegler, A. (1969) Tremorgenic toxin from Penicillium palitans. Appl. Microbiol. 18: 128–129.

    PubMed  Google Scholar 

  • Ciegler, A., S. Kadis & S. J. Ajl (eds.) (1971) Fungal toxins. In ‘Microbial Toxins’, Vol. Vi, 563 pp. Academic Press, New York.

    Google Scholar 

  • Changes in Official Methods of Analysis. (1972) Sec. 26 B01-26 B04. J. Ass. Off Anal. Chem. 55: 399–447.

    Google Scholar 

  • Changes in official methods of analysis made at the 86th annual meeting, October 9–12, 1972. (1973) J. Ass. Off. Anal. Chem. 56: 447–532.

  • Connole, M. D. & M. W. M. Hill (1970) Aspergillus flavus contaminated sorghum grain as a possible cause of aflatoxicosis in pigs. Aust. Vet. J. 46: 503–505.

    PubMed  Google Scholar 

  • Diener, U. L. & N. D. Davis (1969) Aflatoxin formation by Aspergillus flavus. In L. A. Goldblatt (ed.), ‘Aflatoxin. Scientific Background, Control, and Implications,’ pp. 13–54.

  • Enomoto, M. & M. Saito (1972) Carcinogens produced by fungi. Ann. Rev. Microbiol. 26: 279–312.

    Article  Google Scholar 

  • Eppley, R. M. (1968) Screening method for zearalenone, aflatoxin, and ochratoxin. J. Ass. Off. Anal. Chem. 51: 74–78.

    Google Scholar 

  • Eppley, R. M., L. Stoloff & C. W. Chung (1973) Survey of corn for Fusarium toxins. Abstr. 87th Ann. Meeting Ass. Off. Anal. Chem., pp. 40–41.

  • Frank, H. K. & W. Eyrich, (1968) Über den Nachweis von Aflatoxinen und das Vorkommen Aflatoxin-vortäuschender Substanzen in Lebensmitteln. Z. Lebensm.-Unters. Forsch. 138: 1–11.

    Article  Google Scholar 

  • Hamilton, P. B. (1971) A natural and extremely severe occurrence of aflatoxicosis in laying hens. Poultry Sci. 50: 1880–1882.

    Google Scholar 

  • Hamilton, P. B. (1973) Personal communication.

  • Hesseltine, C. W. (1969) Mycotoxins. Mycopathol. Mycol. Appl. 39: 371–383.

    Article  PubMed  Google Scholar 

  • Hesseltine, C. W. & O. L. Shotwell, (1972) New methods for rapid detection of aflatoxin. IUPAC Symposium ‘Control of Mycotoxins’, Kungälv, Sweden, p. 25.

  • Hesseltine, C. W., O. L. Shotwell, J. J. Ellis & R. D. Stubblefield (1966) Aflatoxin formation by Aspergillus flavus. Bacteriol. Rev. 30: 795–805

    PubMed  Google Scholar 

  • Hesseltine, C. W., E. E. Vandegraft, D. I. Fennell, M. L. Smith & O. L. Shotwell (1972) Aspergilli as ochratoxin producers. Mycologia 64: 539–550.

    PubMed  Google Scholar 

  • Hsu, I., E. B. Smalley, F. M. Strong & W. E. Ribelin (1972) Identification of T-2 toxin in moldy corn associated with a lethal toxicosis in dairy cattle. Appl. Microbiol. 24: 684–690.

    PubMed  Google Scholar 

  • Jemmali, M. (1971) La conservation vue sous l'aspect microbiologique. Bull. Anciens Elèves Ecole Fr. Meun. 241: 3–12.

    Google Scholar 

  • Jemmali, M. (1973) Présence d'un facteur oestrogénique d'origine fongique la zearalenone ou F-2, comme contaminant naturel, dans du mais. Ann. Microbiol. (Inst. Pasteur) 124B: 109–114.

    Google Scholar 

  • Jemmali, M. (1973) Personal communication.

  • Kadis, S., A. Ciegler & S. J. Ajl (eds.) (1971) Algal and fungal toxins. In ‘Microbial Toxins,’ Vol. VII, 418 pp. Academic Press, New York.

    Google Scholar 

  • Kadis, S., A. Ciegler & S.J. Ajl (eds.) (1972) Fungal toxins. In ‘Microbial Toxins,’ Vol. VIII, 400 pp. Academic Press, New York.

    Google Scholar 

  • Korpinen, E. L. (1972) Natural occurrence of F-2 and F-2-producing Fusarium strains associated with field cases of bovine and swine infertility. IUPAC Symposium ‘Control of Mycotoxins,’ Kungälv, Sweden, p. 21.

  • Krogh, P. (1970) Survey on the Scandinavian mycotoxin project: Occurrence of aflatoxin in imported foodstuffs. Proc. XI. Nordic Vet. Congr., Bergen, p. 278.

  • Krogh, P. (1972) Natural occurrence of ochratoxin A and citrinin in cereals associated with field outbreaks of swine nephropathy. IUPAC Symposium ‘Control of Mycotoxins,’ Kungälv, Sweden, p. 19.

  • Krogh, P. (1973) Natural occurrence of ochratoxin A and citrinin in cereals associated with swine nephropathy. Abstr. 0360. 2nd Int. Congr. Plant Pathol., Minneapolis, Minnesota.

  • Krogh, P., B. Hald & E. L. Korpinen (1970) Occurrence of aflatoxin in groundnut- and copra-products imported to Finland. Nord. Vet. Med. 22: 584–589.

    Google Scholar 

  • Kurata, H. & H. Tanabe (1973) Natural occurrence of mycotoxins in foodstuffs of Japan. Abstr. 0361. 2nd Int. Congr. Plant Pathol., Minneapolis, Minnesota.

  • Lafont, P. & J. Lafont (1970) Contamination de produits céréaliers et d'aliments du bétail par l'aflatoxine. Fd. Cosmet. Toxicol. 8: 403–408.

    Article  Google Scholar 

  • Lucas, F. V., Jr., P. Monroe, P. V. Nga, J. F. Townsend & F. V. Lucas (1971) Mycotoxin contamination of South Vietnamese rice. J. Trop. Med Hyg. 74: 182–184.

    PubMed  Google Scholar 

  • Main, C. E. & P. B. Hamilton (1972) Animal toxicity of phytopathogenic fungi. Appl. Microbiol. 23: 193–195.

    PubMed  Google Scholar 

  • Mirocha, C. J. & C. M. Christensen, (1973) Estrogenic mycotoxins synthesized by Fusarium. In ‘Mycotoxins,’ I. F. H. Purchase (ed.), Elsevier Press. in press.

  • Mirocha, C. J., C. M. Christensen & G. H. Nelson (1972) Analysisof zearalenone (F-2) and its naturally occurring derivatives. IUPAC Symposium ‘Control of Mycotoxins,’ Kungälv, Sweden, p. 30.

  • Mirocha, C. J., J. Harrison, A. A. Nichols & M. McClintock (1968) Detection of a fungal estrogen (F-2) in hay associated with infertility in dairy cattle. Appl. Microbiol. 16: 797–798.

    PubMed  Google Scholar 

  • Narasimhan, M. J., Jr. (1968) On the presence of aflatoxins in copra. Hindustan Antibiot. Bull. 11: 104–105.

    PubMed  Google Scholar 

  • Nesheim, S. (1971) Ochratoxins: Occurrence, production, analysis, and toxicity. Abstr. 85th Ann. Meeting Ass. Off. Anal. Chem. p. 23.

  • Norstadt, F. A. & T. M. McCalla (1969) Microbial populations in stubble-mulched soil. Soil. Sci. 107: 188–193.

    Google Scholar 

  • Official Methods of Analysis. (1970) Ass. Off. Anal. Chem., 11th ed., Sec. 26.015–26.019.

  • Ošegović, L. (1970) Mouldy maize poisoning in pigs. Veterinaria (Sarajevo) 19: 525–531. [See Rev. Med. Vet. Mycol. 7: 592 (1972)].

    Google Scholar 

  • Purchase, I. F. H. (1972) Aflatoxin residues in food of animal origin.Fd. Cosmet. Toxicol. 10: 531–544.

    Article  Google Scholar 

  • Purchase, I. F. H. & T. Goncalves (1971) Preliminary results from food analyses in the Inhambane area. In I. F. H. Purchase (ed.), ‘Symposium on Mycotoxins in Human Health,’ pp. 263–269.

  • Raper, K. B. & D. I. Fennell (1965) The genus Aspergillus, Williams & Wilkins Co., Baltimore, Maryland, 686 pp.

    Google Scholar 

  • Raper, K. B. & C. Thom (1949) A manual of the Penicillia, Williams & Wilkins Co., Baltimore, Maryland, 875 pp.

    Google Scholar 

  • Raymond, W. D. (1966) Mycotoxin problems in the United Kingdom and the tropics. Food Technol. 20: 904–910.

    Google Scholar 

  • Schroeder, H. W. & R. A. Boller, (1973) Aflatoxin production of species and strains of the Aspergillus flavus group isolated from field crops. Appl. Microbiol. 25: 885–889.

    PubMed  Google Scholar 

  • Schultz, J. & R. Motz (1967) Toxinbildende Aspergillus flavus Stämme in Futtermitteln. Arch. Exp. Vet. 21: 129–140.

    Google Scholar 

  • Scott, D. B. (1965) Toxigenic fungi isolated from cereal and legume products. Mycopathol. Mycol. Appl. 25: 213–222.

    Article  PubMed  Google Scholar 

  • Scott, P. M. (1972) Occurrence of ochratoxin A and citrinin in grains and patulin in apple juice. IUPAC Symposium ‘Control of Mycotoxins,’ Kungälv, Sweden, p. 20.

  • Scott, P. M., W. van Walbeek, J. Harwig & D. I. Fennell (1970) Occurrence of a mycotoxin, ochratoxin A, in wheat and isolation of ochratoxin A and citrinin producing strains of Penicillium viridicatum. Can. J. Plant Sci. 50: 583–585.

    Google Scholar 

  • Scott, P. M., W. van Walbeek, B. Kennedy & D. Anyeti (1972) Mycotoxins (ochratoxin A, citrinin, and sterigmatocystin) and toxigenic fungi in grains and other agricultural products. J. Agr. Food Chem. 20: 1103–1109.

    Article  Google Scholar 

  • Shank, R. C., G. N. Wogan, J. B. Gibson, & A. Nondasuta (1972) Dietary aflatoxins and human liver cancer. II. Aflatoxins in market foods and foodstuffs of Thailand and Hong Kong. Fd. Cosmet. Toxicol. 10: 61–69.

    Article  Google Scholar 

  • Shotwell, O. L. & R. J. Bothast (1973) Analyses of corn samples from Yugoslavia. Personal communication.

  • Shotwell, O. L., M. L. Goulden & C. W. Hesseltine (1972) Aflatoxin contamination: Association with foreign material and characteristic fluorescence in damaged corn kernels. Cereal Chem. 49: 458–465.

    Google Scholar 

  • Shotwell, O. L., C. W. Hesseltine, H. R. Burmeister, W. F. Kwolek, G. M. Shannon & H. H. Hall (1969a) Survey of cereal grains and soybeans for the presence of aflatoxin: I. Wheat, grain sorghum, and oats. Cereal Chem. 46: 446–454.

    Google Scholar 

  • Shotwell, O. L., C. W. Hesseltine, H. R. Burmeister, W. F. Kwolek, G. M. Shannon & H. H. Hall (1969b) Survey of cereal grains and soybeans for the presence of aflatoxins. II. Corn and soybeans. Cereal. Chem. 46: 454–463.

    Google Scholar 

  • Shotwell, O. L., C. W. Hesseltine & M. L. Goulden (1969c) Note on the natural occurrence of ochratoxin A. J. Ass. Off. Anal. Chem. 52: 81–83.

    Google Scholar 

  • Shotwell, O. L., C. W. Hesseltine & M. L. Goulden (1973) Incidence of aflatoxin in southern corn, 1969–1970. Cereal Sci. Today 18: 192–195.

    Google Scholar 

  • Shotwell, O. L., C. W. Hesseltine, M. L. Goulden & E. E. Vandegraft (1970) Survey of corn for aflatoxin, zearalenone, and ochratoxin. Cereal Chem. 47: 700–707.

    Google Scholar 

  • Shotwell, O. L., C. W. Hesseltine, E. E. Vandegraft & M. L. Goulden (1971) Survey of corn from different regions for aflatoxin, ochratoxin, and zearalenone. Cereal Sci. Today 16: 266–273.

    Google Scholar 

  • Shotwell, O. L., G. M. Shannon, M. L. Goulden, M. S. Milburn & H. H. Hall (1968) Factors in oats that could be mistaken for aflatoxin. Cereal Chem. 45: 236–241.

    Google Scholar 

  • Smith, J. W. & P. B. Hamilton (1970) Aflatoxicosis in the broiler chicken. Poultry Sci. 49: 207–215.

    Google Scholar 

  • Spicher, G. (1970) Untersuchungen über das Vorkommen von Aflatoxin in Brot. Centbl. Bakt. Parasit. II 124: 697–706.

    Google Scholar 

  • Thorpe, C. W. (1973) Analysis of penicillic acid by GLC. Abstr. 87th Ann. Meeting Ass. Off. Anal. Chem., p. 40.

  • Tripathi, R. K. (1973) Aflatoxins in the sorghum grains infected with head moulds. Indian J. Exp. Biol. In press.

  • Tung, H. T. & P. B. Hamilton (1973) Decreased plasma carotenoids during aflatoxicosis. Poultry Sci. 52: 80–83.

    Google Scholar 

  • Tung, T. C. & K. H. Ling (1968) Study of aflatoxin of foodstuffs in Taiwan. J. Vitaminol. 14: 48–52.

    Google Scholar 

  • Umetsu, N., J. Kaji & K. Tamari (1973) Isolation of tenuazonic acid from blastdiseased rice plants. Agr. Biol. Chem. 37: 451–452.

    Google Scholar 

  • Van Walbeek, W. (1973) Fungal toxins in foods, Can. Inst. Food Sci. Technol. J. 6: 96–105.

    Google Scholar 

  • Van Walbeek, W., P. M. Scott & F. S. Thatcher (1968) Mycotoxins from food-borne fungi. Can. J. Microbiol. 14: 131–137.

    PubMed  Google Scholar 

  • Watson, S. A. & K. R. Yahl (1971) Survey of aflatoxins in commercial supplies of corn and grain sorghum used for wet-milling. Cereal Sci. Today 16: 153–155, 163.

    Google Scholar 

  • Wilson, B. J., P. A. Teer, G. H. Barney & F. R. Blood (1967) Relationship of aflatoxin to epizootics of toxic hepatitis among animals in southern United States. Amer. J. Vet. Res. 28: 1217–1230.

    PubMed  Google Scholar 

  • Wogan, G. N. (1968) Aflatoxin risks and control measures. Fed. Proc. 27: 932–938.

    PubMed  Google Scholar 

  • Yahl, K. R., S. A. Watson, R. J. Smith & R. Barabolok (1971) Laboratory wet-milling of corn containing high levels of aflatoxin and a survey of commercial wet-milling products. Cereal Chem. 48: 385–391.

    Google Scholar 

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Hesseltine, C.W. Natural occurrence of mycotoxins in cereals. Mycopathologia et Mycologia Applicata 53, 141–153 (1974). https://doi.org/10.1007/BF02127204

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