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Onset of action of captopril, enalapril, enalaprilic acid and lisinopril in normal man

  • Focussed Section: ACE Inhibitors
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Summary

The effects of orally administered captopril, enalapril and lisinopril on plasma concentrations of angiotensin converting enzyme (ACE), angiotensin II (ANGII) and renin (PRC) were studied over a period of 6 hours in 6 normal subjects. A further 4 subjects received intravenous enalapril and enalaprilic acid (enalaprilat). Captopril (25 mg) by mouth caused a fall in pANGII that reached a nadir 30 to 40 minutes after administration but an effect was hardly apparent after 6 hours. Enalapril (10 mg) by mouth had less marked effects on pACE and pANGII with a decline in levels first apparent 1 hour after administration and the lowest levels reached between 3 and 6 hours. Lisinopril (10 mg) produced a progressive fall in pACE and pANGII from 1 hour to reach the lowest values 6 hours after treatment. Intravenous enalaprilat (5 mg) produced an immediate sustained fall in both pACE and pANGII but intravenous enalapril (7 mg) had a biphasic inhibitory effect.

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Authors and Affiliations

  1. MRC Blood Pressure Unit, Western Infirmary, G11 6NT, Glasgow

    P. F. Semple, A. M. M. Cumming, P. A. Meredith & J. J. Morton

  2. University Department of Materia Medica, Stobhill Hospital, G20, Glasgow

    P. A. Meredith

Authors
  1. P. F. Semple
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  2. A. M. M. Cumming
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  3. P. A. Meredith
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  4. J. J. Morton
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Semple, P.F., Cumming, A.M.M., Meredith, P.A. et al. Onset of action of captopril, enalapril, enalaprilic acid and lisinopril in normal man. Cardiovasc Drug Ther 1, 45–50 (1987). https://doi.org/10.1007/BF02125832

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  • DOI: https://doi.org/10.1007/BF02125832

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