Abstract
In 238 boys with cryptorchidism, between the ages of 4 and 48 months, luteinizing hormone releasing hormone (LHRH) was administered as nasal spray 1.2 mg/day for 4 weeks. The nonresponders received human chorionic gonadotropin (HCG) 500 I.U. i.m. three times a week for 3 weeks. With the combined treatment, 37.8% of testes descended into the scrotum. Testicular descent occurred more often in patients whose testes were located in a lower position. Histological findings indicated a reduction in the number and maturation of germ cells. A clear improvement of germ cells trophism was observed in boys hormonally treated and operated on before the 12th month of life. Early administered combined treatment with LHRH and HCG can be considered as a substitution of the gonadotropins insufficiency manifested by most cryptorchid infants in the first months of life.
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Abbreviations
- LHRH :
-
Luteinizing hormone releasing hormone
- HCG :
-
Human chorionic gonadotropin
- Ad :
-
Spermatogonia: Adult dark spermatogonia
References
Bierich J (1979) Clinical treatment of maldescensus testis. In Bierich J, Giarola A (eds) Cryptorchidism. Academic Press, London New York, pp 375–389
Hadziselimovic F (1977) Cryptorchidism: ultrastructure of normal and cryptorchid testis development. In: Adv Anat Embryol Cell Biol 53 Springer, Berlin Heidelberg, pp 3–72
Hadziselimovic F, Herzog B (1987) Cryptorchidism. Pediatr Surg Int 2:132–141
Hadziselimovic F, Herzog G (1990) Kryptorchismus. In: Daum R, Mildenberger H, Rehbein F (eds) Hodenerkrankungen im Kindesalter. Hippokrates, Stuttgart, pp 24–72
Hadziselimovic F, Girard J, Herzog B (1984) Four years' experience with a combined hormonal therapy of cryptorchidism. Kinderchirurgie 39:324–327
Hagberg S, Westphal O (1987) Results of combined hormonal and surgical treatment for undescended testes in boys under 3 years of age. In: Hadziselimovic F, Herzog B, Girard J (eds) Cryptorchidism. Eur J Pediatr [Suppl. 2] 146:S38–S39
Hedinger C (1979) Histopathology of the cryptorchid testis. In: Bierich JR, Giarola A (eds) Cryptorchidism. Academic Press, London New York, pp 29–38
Huff D, Hadziselimovic F, McC Snyder H, Blyth B, Duckett JW Early postnatal testicular maldevelopment in cryptorchidism. J Urol 146:624–626
Illig R, Kollmann L, Borkenstein M, Kuber W, Exner G, Kellerer K, Lungmayr L, Prader A (1977) Treatment of cryptorchidism by intranasal synthetic luteinizing hormone releasing hormone. Results of a collaborative study. Lancet II:518–520
Lala R, de Sanctis C, Canavese F, Bardini T, Hadziselimovic F (1922) Early medical and surgical treatment of cryptorchidism: clinical, anatomic and histologic findings. Pediatr Surg. Int 7:368–371
Schindler A, Diaz P, Cuendet A, Sizonenko P (1987) Cryptorchidism: a morphological study of 670 biopsies. Helv Paediatr Acta 42:145–158
Scorer CG (1964) The descent of the testis. Arch Dis Child 39:605–609
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Lala, R., Matarazzo, P., Chiabotto, P. et al. Combined therapy with LHRH and HCG in cryptorchid infants. Eur J Pediatr 152 (Suppl 2), S31–S33 (1993). https://doi.org/10.1007/BF02125433
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DOI: https://doi.org/10.1007/BF02125433