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Mechanism of recovery from acute virus infection

III. Subclass of T lymphocytes mediating clearance of lymphocytic choriomeningitis virus from the spleens of mice

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Abstract

Spleen T lymphocytes from mice undergoing acute infection with lymphocytic choriomentingitis virus (LCM virus) were negatively selected by treatment with anti-Lyt or anti-L3T4 antibodies and complement. The subsets thus obtained were tested for their potential to lyse LCM virus-infected target cells in vitro and to confer on infected syngeneic recipients the ability to eliminate virus rapidly from their spleens. Both capacities were found to be associated with Lyt-1−2+, L3T4− cells. Previous studies had shown that LCM virus-specific cytotoxicity in vitro as well as reduction of replication of LCM virus in the adoptively immunized mouse requires compatibility at K and/or D of the major histocompatibility complex, and we conclude that clearance of LCM virus from the mouse's spleen is mediated by the subset of T lymphocytes that is functionally characterized as cytotoxic/suppressive.

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Authors and Affiliations

  1. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Federal Republic of Germany

    U. Assmann-Wischer & F. Lehmann-Grube

  2. Max-Planck-Institut für Immunbiologie, D-7800, Freiburg, Federal Republic of Germany

    M. M. Simon

Authors
  1. U. Assmann-Wischer
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  2. M. M. Simon
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  3. F. Lehmann-Grube
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Assmann-Wischer, U., Simon, M.M. & Lehmann-Grube, F. Mechanism of recovery from acute virus infection. Med Microbiol Immunol 174, 249–256 (1985). https://doi.org/10.1007/BF02124809

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  • DOI: https://doi.org/10.1007/BF02124809

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