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Steigerungsfähigkeit von Kontraktionsgeschwindigkeit und Schlagvolumen durch inotrope Mechanismen beim intakten Herzen in situ

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Literatur

  1. Abbott, B. C. andW. F. H. M. Mommaerts, A study of inotropic mechanisms in the papillary muscle preparation. J. Gen. Physiol.42, 533 (1959).

    PubMed  Google Scholar 

  2. Antoni, H. R. Jacob undR. Kaufmann, Mechanische Reaktionen des Frosch- und Warmblütermyocards bei künstlicher Verkürzung und Verlängerung der Aktionspotentialdauer. Frühjahrstagung Deutsch. Physiol. Ges., Mainz 1968, Pflügers Arch. Physiol. (im Druck).

  3. Arnold, G., F. Koschke, K. Zinganell undW. Lochner, Bceinflussung des O2-Verbrauchs des Herzens durch den coronaren Perfusionsdruck. Pflügers Arch. Physiol.289, R54 (1966).

    Google Scholar 

  4. Åstrand, J., T. E. Cuddy, J. Lundgren, R. O. Malmberg, andB. Saltin, Hemodynamic responses to exercise during atrial flutter and sinus rhythm. Acta Med. Scand.173, 121 (1963).

    Google Scholar 

  5. Åstrand, P., T. E. Cuddy, B. Saltin, andJ. Sternberg, Cardiac output during submaximal and maximal work. J. appl. Physiol.19, 268 (1964).

    PubMed  Google Scholar 

  6. Bartelstone, J. H., B. J. Scherlag, B. F. Hoffman, andP. F. Cranefield, Demonstration of variable diastolic compliance associated with paired stimulation of the dog heart. Bull. N. Y. Acad. Med.41, 616 (1965).

    PubMed  Google Scholar 

  7. Bauerseisen, E., G. Hauck, R. Jacob undU. Peiper, Enddiastolische Druck-Volumen-Relationen und Arbeitsdiagramme des intakten Herzens im natürlichen Kreislauf in Abhängigkeit von Herzfrequenz, Adrenalinwirkung und Vagusrciz. Pflügers Arch. Physiol.281, 216 (1964).

    Google Scholar 

  8. Bauereisen, E., R. Jacob, U. Kleinheisterkamp, U. Peiper undK. H. Weigand, Enddiastolische Dehnbarkeit des linken Ventrikels bei akuten Änderungen des arteriellen Systemdrucks. Pflügers Arch. Physiol.285, 355 (1965).

    Google Scholar 

  9. Benchimol, A., Y. Li, andG. Dimond, Cardiovascular dynamics in complete heart block at various heart rates. Effect of exercise at a fixed heart rate. Circulation30, 542 (1964).

    PubMed  Google Scholar 

  10. Bevegård, S., Observations on the effect of varying ventricular rate on the circulation at rest and during exercise in two patients with an artificial pacemaker. Acta med. Scand.172, 615 (1962).

    PubMed  Google Scholar 

  11. Bevegård, S., A. Holmgren, andB. Jonsson, Circulatory studies in well trained athletcs at rest and during heavy exercise, with special reference to stroke volume and the influence of body position. Acta physiol. scand.57, 26 (1963).

    PubMed  Google Scholar 

  12. Blinks, J. R. andJ. Koch-Weser, Analysis of the effects of changes in rate and rhythm upon myocardial contractility. J. Pharmacol. exper. Ther.134, 373 (1961).

    Google Scholar 

  13. Brady, A. J., Development of tension in cardiac muscle. Pharmacology of cardiac function, p. 15 (London 1964).

  14. Braunwald, E., A. Goldblatt, D. C. Harrison, andD. T. Mason, Studies on cardiac dimensions in intact unanesthesized man: III. Effects of muscular excreise. Circulation Research13, 460 (1963).

    Google Scholar 

  15. Braunwald, E., E. H. Sonnenblick, J. Ross, G. Glick, andSt. E. Epstein, An analysis of the cardiac responses to exercise. Suppl. I to Circul. Res.20/21, 44 (1967).

    Google Scholar 

  16. Braunwald, E., J. R. Ross, P. L. Frommer, J. F. Williams, E. Sonnenblick, andJ. H. Gault, Clinical observations on paired electrical stimulation of the heart. Effects on ventricular performance and heart rate. Amer. J. Med.37, 700 (1964).

    PubMed  Google Scholar 

  17. Braunwald, E., J. Ross, E. H. Sonnenblick, P. L. Frommer, N. S. Braunwald, andA. G. Morrow, Slowing of heart rate, electroaugmentation of ventricular performance and increase of myocardial oxygen consumption produced by paired electrical stimulation. Bull. New York Acad. Med.41, 481 (1965).

    Google Scholar 

  18. Bruce, Th. A., C. B. Chapman, O. Baker, andJ. N. Fisher, The role of autonomic and myocardial factors in cardiac control. J. clin. invest.42, 721 (1963).

    PubMed  Google Scholar 

  19. Brutsaert, D., Influence of different stimulation frequencies on the cardiac output at rest and during moderate exercise in dogs with chronic atrioventricular heart block. Acta Cardiologica20, 469 (1965).

    PubMed  Google Scholar 

  20. Cerretelli, P., J. Pijper, F. Mangili, F. Cuttica, andB. Ricci, Circulation in exercising dogs. J. appl. Physiol.19, 29 (1964).

    PubMed  Google Scholar 

  21. Chapman, C. B., J. N. Fisher, andB. J. Sproule, Behaviour of stroke volume at rest and during exercise in human beings. J. Clin. Invest.39, 1208 (1960).

    PubMed  Google Scholar 

  22. Cranefield, P. F., The force of contraction of extrasystoles and the potentiation of force of the postextrasystolic contraction: A historical review. Bull. N. Y. Acad. Med.41, 419 (1965).

    Google Scholar 

  23. Cranefield, P. F., B. J. Scherlag, B. K. Yeh, andB. F. Hoffman, Treatment of acute cardiac failure by maintained postextrasystolic potentiation. Bull. N. Y. Acad. Med.40, 903 (1964).

    PubMed  Google Scholar 

  24. Donald, E. D. andJ. T. Shepherd, Response to exercise in dogs with cardiac denervation. Amer. J. Physiol.205, 393 (1963).

    PubMed  Google Scholar 

  25. Downing, S. E. andE. H. Sonnenblick, Cardiac muscle mechanics and ventricular performance: force and time parameters. Amer. J. Physiol.207, 705 (1964).

    PubMed  Google Scholar 

  26. Edman, K. A. P., D. W. Grieve, andE. Nilsson, Studies of the excitationcontraction mechanism in the skeletal muscle and the myocardium. Pflügers Arch. ges. Physiol.290, 320 (1966).

    Google Scholar 

  27. Ekelund, L. G. andA. Holmgren, Central hemodynamics during exercise. Suppl. I to Circul. Res.20/21, 33 (1967).

    Google Scholar 

  28. Epstein, S. E., B. F. Robinson, R. L. Kahler, andE. Braunwald, Effects of beta-adrenergic blockade on the cardiac response to maximal and submaximal exercise in man. J. Clin. Invest.44, 1745 (1965).

    PubMed  Google Scholar 

  29. Feigl, E. O., Effects of stimulation frequency on myocardial extensibility. Circul. Res.20, 447 (1967).

    Google Scholar 

  30. Fisher, V. J., R. J. Lee, A. M. Marlon, andF. Kavaler, Paired electrical stimulation and the maximal contractile response of the ventricle. Circul. Res.20, 520 (1967).

    Google Scholar 

  31. Fleckenstein, A., H., Kammermeier, H. J. Döring undH. J. Freund, Zum Wirkungsmechanismus neuartiger Koronardilatatoren mit gleichzeitig Sauerstoff-einsparenden Myocardeffekten, Prenylamin und Iproveratril. Z. Kreislaufforschg.56, 716 (1967).

    Google Scholar 

  32. Frank, O., Die Wirkung von Digitalis (Helleborein) auf das Herz. Sitzber. Ges. Morph. u. Physiol.14, 14 (1898).

    Google Scholar 

  33. Gauer, O. H. andH. L. Thron, Postural changes in the circulation. Handbook of Physiology, Section2, Vol. III 2409 (1965).

    Google Scholar 

  34. Geiil, H., K. Graf undK. Kramer, Das Druck-Volumendiagramm des Kaltblüterherzens. Pflüg. Arch. Physiol.261, 270 (1955).

    Google Scholar 

  35. Gilmore, J. P., H. E. Cingolani, R. R. Taylor, andR. H. McDonald, Physical factors and cardiac adaption. Amer. J. Physiol.211, 1219 (1966).

    PubMed  Google Scholar 

  36. Gilmore, J. P., H. E. Cingolani, R. R. Taylor, andW. J. Powell, Influence of ventrikular activation on ventrikular compliance. Amer. J. Physiol.211, 1227 (1966).

    PubMed  Google Scholar 

  37. Glick, G., E. H. Sonnenblick, andE. Braunwald, Myocardial force-veloctiy studies in intact unanesthetized men. J. Clin. Invest.44, 978 (1965).

    PubMed  Google Scholar 

  38. Glick, G., J. F. Williams, D. G. Harrison, A. G. Morrow, andE. Braunwald, Cardiac dimensions in intact unanesthetized man. VI. Effects of changes in heart rate. J. appl. Physiol.21, 947 (1966).

    PubMed  Google Scholar 

  39. Graham, T. P., W. J. Powell, R. L. Clany, andJ. P. Gilmore, Characterization of the frequency-force relationship in the dog atrium in situ. Circul. Res.20, 338 (1967).

    Google Scholar 

  40. Hahn, N., H. Schaefer, andH. Weidinger, The differential quotient of QRS as a measure of the sympathetic tonization of the myocardium. Cardiologia48, 224 (1966).

    Google Scholar 

  41. Heppner, R. L., S. Weidmann, andE. H. Wood, Positive and negative inotropic effects by constant electric currents or current pulses applied during the cardiac action potential. Helv. Physiol. Acta24, C 94 (1966).

    Google Scholar 

  42. Hoffman, B. F., H. J. Bartelstone, B. J. Scherlag, Der Kontraktionskraft und Verlangsamung der Frequenz des Herzens. Anaesthesiologie und Wiederbelebung15, 123 (1966). andP. F. Cranefield, Effects of postextrasystolic potentiation on normal and failing hearts. Bull. N. Y. Acad. Med.41, 498 (1965).

    Google Scholar 

  43. Hoffman, B. F., E. Bindler, andE. E. Suckling, Postextrasystolic potentiation of contraction in cardiac muscle. Amer. J. Physiol.185, 95 (1956).

    PubMed  Google Scholar 

  44. Holmgren, A., Circulatory changes during muscular work in man. Scand. J. Clin. Lab. invest. Suppl.24, 1–96 (1956).

    Google Scholar 

  45. Jacob, R., a) Kontraktions- und Relaxationsphasen des Warmblüterherzens in situ bei normaler und herabgesetzter Kontraktilität; b) Druck-Volumen-Zeitbeziehungen im Tierexperiment, in:Reindell, H., J. Keul u.E. Doll, „Herzinsuffizienz, Pathophysiologie und Klinik”. Hinterzarten 1967 (Georg Thieme Stuttgart 1968).

  46. Jacob, R. undK. H. Weigand, Die endsystolischen Druck-Volumenbeziehungen als Grundlage einer Beurteilung der Kontraktilität des linken Ventrikels in situ Pflügers Arch. ges. Physiol.289, 37 (1966).

    Google Scholar 

  47. Jacob, R., G. Kissling, E. E. Ohnhaus undJ. Segarra-Domenech, Kontraktilitätssteigerung des nicht hypodynamen Herzens durch postextrasystolische Potentiation. 32. Tagg. Dtsch. Physiol. Ges. Berlin 1966. Pflügers Arch. Physiol.291, 11 (1966).

    Google Scholar 

  48. Jacob, R., G. Kissling, E. E. Ohnhaus, U. Peiper undJ. Segarra-Domenech, Die „Kontraktilität” des suffizienten Herzens unter rechtsventrikulärem Schrittmacherantrieb. Arch. Kreislaufforschg.54, 192 (1967).

    Google Scholar 

  49. Kaufmann, R., A. Fleckenstein undH. Antoni, Ursache und Auslösungsbedingungen von Myocard-Kontraktionen ohne reguläres Aktionspotential. Arch. Ges. Physiol.278, 435 (1963).

    Google Scholar 

  50. Kavaler, F., V. J. Fisher, andJ. H. Stuckey, The potentiated contraction and ventricular “contractility”. Bull. N. Y. Acad. Med.41, 592 (1965).

    PubMed  Google Scholar 

  51. Kerth, W. J. andJ. J. Kelly, Experience with paired pacing in experimental canine heart failure. Bull. N. Y. Acad. Med.41, 646 (1965).

    PubMed  Google Scholar 

  52. Koch-Weser, J., Potentiation of myocardial contractility by continual premature extraactivations. Circul. Res.18, 330 (1966).

    Google Scholar 

  53. Köhler, R., W. Rutishauser, M. Gander undI. Babotai, Veränderungen der Dynamik des linken Ventrikels des Hundes unter paariger Stimulation vor und nach Beta-Blockade. Cardiologia (Basel)49, 135 (1966).

    Google Scholar 

  54. Langendorff, O., Über elektrische Reizung des Herzens. Arch. Physiol. (Arch. Anat. Physiol., Phys. Abt.) 284 (1885).

  55. Lopez, J. F., Elelist, A., andL. N. Katz, Reducing heart rate of the dog by electrical stimulation. Circul. Res.15, 414 (1964).

    Google Scholar 

  56. Marshall, R. J. andJ. T. Shepherd, Exercise and the Circulation. Circul.27, 323 (1963).

    Google Scholar 

  57. Meijler, F. L. andD. Durrer, Physiological and clinical aspects of paired stimulation. Bull. N. Y. Acad. Med.41, 575 (1965).

    PubMed  Google Scholar 

  58. Miller, E., W. L. Gleason, R. E. Whalen, J. J. Morris, andH. D. McIntosh, Effect of ventricular rate on the cardiac output in the dog with chronic heart block. Circul. Res.10, 658 (1962).

    Google Scholar 

  59. Mitchell, J. H., B. J. Sproule, andC. B. Chapman, The physiological meaning of the maximal oxygen intake test. J. clin. Invest.37, 538 (1958).

    PubMed  Google Scholar 

  60. Musshoff, K., H. Reindell, H. Steim undK. König, Die Sauerstoffaufnahme pro Herzschlag (O2-Puls) als Funktion des Schlagvolumens, der arteriovenösen Differenz, des Minutenvolumens und des Herzvolumens. Z. Kreislaufforschg.48, 255 (1959).

    Google Scholar 

  61. Niedergerke, R., Staircase phenomenon and the action of calcium on the heart. J. Physiol. (London)134, 569 (1956).

    Google Scholar 

  62. Noble, M. I. M., D. Trenchard, andA. Guz, Left ventricular cjection in conscious dogs: II. Determinants of stroke volume. Circul. Res.19, 148 (1966).

    Google Scholar 

  63. Reichel, H., Diskussionsbeitrag. Proc. of the Internat. Union of Physiological Sciences, 22. Internat. Congress, Leiden, Vol. I,, p. 167 (1962).

    Google Scholar 

  64. Reiter, M., Die Entstehung von „Nachkontraktionen” im Herzmuskel unter Einwirkung von Calcium und von Digitalisglykosiden in Abhängigkeit von der Reizfrequenz. Naunyn-Schmiedebergs Arch. exp. Path. Pharmakol.242, 497 (1962).

    Google Scholar 

  65. Ross, J., J. W. Linhart, andE. Braunwald, Effects of changing heart rate in man by electrical stimulation of the right atrium: Studies at rest, during exercise, and with isoproterenol. Circulation32, 549 (1965).

    PubMed  Google Scholar 

  66. Ross, J., E. H. Sonnenblick, G. A. Kaiser, P. L. Frommer, andE. Braunwald, Electroaugmentation of ventricular performance and oxygen consumption by repititive application of paired electrical stimuli. Circul. Res.16, 332 (1965).

    Google Scholar 

  67. Rushmer, R. F., Constancy of stroke volume in ventricular responses to exertion. Amer. J. Physiol.196, 745 (1959).

    PubMed  Google Scholar 

  68. Rushmer, R. F. andO. A. Smith, Cardiac control. Physiol. Reviews39, 41 (1959).

    Google Scholar 

  69. Rutishauser, W., M. Gander undM. Turina, Paarige Stimulation zur Verstärkung

  70. Sarnoff, S. J., J. P. Gilmore, W. J. Daggett, P. B. Mansfield, M. L. Weisfeldt, andR. M. McDonald, Myocardial dynamics, contractility, O2 consumption and K+ balance during paired stimulation. Amer. J. Physiol.211, 376 (1966).

    PubMed  Google Scholar 

  71. Sarnoff, S. J., J. H. Mitchell, J. P. Gilmore, andJ. P. Remensnyder, Homeometric autoregulation in the heart. Circulation Res.8, 1077 (1960).

    PubMed  Google Scholar 

  72. Schaper, W. K. A., P. Lewi, andA. H. M. Jagenau, The determinantes of the rate of change of the left ventricular pressure (dP/dt). Arch. Kreislaufforschg.46, 27 (1965).

    Google Scholar 

  73. Schwarzkopf, H. J., J. Schaefer, W. Niedermayer, K. Held undF. Ulmer, Der Einfluß der gepaarten Elektrostimulation mit unterschiedlichen Reizfrequenzen auf die Kontraktionskraft des Hundeherzens in situ. Verh. Dtsch. Ges. Kreislaufforschg.33, 161 (Darmstadt 1967).

    Google Scholar 

  74. Shepherd, J. T., Behaviour of resistance and capacity vessels in human limbs. Suppl. I to Circul. Res.20/21 70 (1967).

    Google Scholar 

  75. Siebens, A. A., B. F. Hoffman, andP. F. Cranefield, Ventricular excitability and contractility. Amer. J. Physiol.183, 662 (1955).

    Google Scholar 

  76. Siegel, J. H. andE. H. Sonnenblick, Isometric timetension relationships as an index of myocardial contractility. Circul. Res.12, 597 (1965).

    Google Scholar 

  77. Singer, D. H., G. Galst, andM. L. Wagner, Effects of sustained paired stimulation of the heart in normal dogs and in dogs following coronary artery ligation. Bull. N. Y. Acad. Med.41, 652 (1965).

    PubMed  Google Scholar 

  78. Sonnenblick, E. H., Force-velocity relations in mammalian heart muscle. Amer. J. Physiol.202, 931 (1962).

    PubMed  Google Scholar 

  79. Sonnenblick, E. H., Determinants of active state in heart muscle: Force, velocity, instantaneous muscle length, time. Fed. Proc.24, 1296 (1965).

    Google Scholar 

  80. Sonnenblick, E. H., Diskussionsbemerkung. Bull. N. Y. Acad. Med.41, 721/722 (1965).

    Google Scholar 

  81. Sonnenblick, E. H., P. L., Frommer, andE. Braunwald, Electroaugmentation of human and cat papillary muscle produced by paired electrical stimulation. Bull. N. Y. Acad. Med.41, 554 (1965).

    PubMed  Google Scholar 

  82. Sonnenblick, E. H., J. Ross, J. W. Covell, andE. Braunwald, Alterations in resting length-tension relations of cardiac muscle induced by changes in contractile force. Circul. Res.19, 980 (1966).

    Google Scholar 

  83. Sonnenblick, E. H., J. Ross, J. W. Covell, G. A. Kaiser, andE. Braunwald, Velocity of contraction as a determinant of myocardial oxygen consumption. Amer. J. Physiol.209, 919 (1965).

    PubMed  Google Scholar 

  84. Stein, E., A. N. Damato, B. D. Kosowsky, S. H. Lau, andJ. W. Lister, The relation of heart rate to cardiovascular dynamics. Pacing by atrial electrodes. Circulation33, 525 (1966).

    Google Scholar 

  85. Tatooles, C. J. andN. S. Braunwald, The comparative hemodynamic effects of paired and single electrical stimulation of the heart: observation in animals with complete heart block and myocardial failure. Bull. N. Y. Acad. Med.41, 681 (1965).

    PubMed  Google Scholar 

  86. Ullrich, K. J., R. Rieker undK. Kramer, Das Druckvolumendiagramm des Warmblüterherzens. Isometrische Gleichgewichtskurven. Pflügers Arch. Physiol.259, 481 (1954).

    Google Scholar 

  87. Wallace, A. G., W. G. Troyer, A. Lesage, andE. F. Zotti, Electrophysiologic effects of isoproterenol and beta blocking agents in awake dogs. Circul. Res.18, 140 (1966).

    Google Scholar 

  88. Warner, H. R. andA. F. Toronto, Regulation of cardiac output through stroke volume. Circul. Res. 8, 549 (1960).

    Google Scholar 

  89. Wetterer, E., Eine neue manometrische Sonde mit elektrischer Transmission. Z. Biol.101, 332 (1943).

    Google Scholar 

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Mit Unterstützung der Deutschen Forschungsgemeinschaft. — Ein Teil der Ergebnisse wurde auf der 32. Tagung der Deutschen Physiologischen Gesellschaft (Berlin, 1966) (47) sowie anläßlich des Internat. Symposions über Herzinsuffizienz, Hinterzarten 1967 (45) vorgetragen.

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Jacob, R., Kissling, G. & Segarra-Domenech, J. Steigerungsfähigkeit von Kontraktionsgeschwindigkeit und Schlagvolumen durch inotrope Mechanismen beim intakten Herzen in situ. Archiv für Kreislaufforschung 57, 291–323 (1968). https://doi.org/10.1007/BF02119483

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