Literatur
Abbott, B. C. andW. F. H. M. Mommaerts, A study of inotropic mechanisms in the papillary muscle preparation. J. Gen. Physiol.42, 533 (1959).
Antoni, H. R. Jacob undR. Kaufmann, Mechanische Reaktionen des Frosch- und Warmblütermyocards bei künstlicher Verkürzung und Verlängerung der Aktionspotentialdauer. Frühjahrstagung Deutsch. Physiol. Ges., Mainz 1968, Pflügers Arch. Physiol. (im Druck).
Arnold, G., F. Koschke, K. Zinganell undW. Lochner, Bceinflussung des O2-Verbrauchs des Herzens durch den coronaren Perfusionsdruck. Pflügers Arch. Physiol.289, R54 (1966).
Åstrand, J., T. E. Cuddy, J. Lundgren, R. O. Malmberg, andB. Saltin, Hemodynamic responses to exercise during atrial flutter and sinus rhythm. Acta Med. Scand.173, 121 (1963).
Åstrand, P., T. E. Cuddy, B. Saltin, andJ. Sternberg, Cardiac output during submaximal and maximal work. J. appl. Physiol.19, 268 (1964).
Bartelstone, J. H., B. J. Scherlag, B. F. Hoffman, andP. F. Cranefield, Demonstration of variable diastolic compliance associated with paired stimulation of the dog heart. Bull. N. Y. Acad. Med.41, 616 (1965).
Bauerseisen, E., G. Hauck, R. Jacob undU. Peiper, Enddiastolische Druck-Volumen-Relationen und Arbeitsdiagramme des intakten Herzens im natürlichen Kreislauf in Abhängigkeit von Herzfrequenz, Adrenalinwirkung und Vagusrciz. Pflügers Arch. Physiol.281, 216 (1964).
Bauereisen, E., R. Jacob, U. Kleinheisterkamp, U. Peiper undK. H. Weigand, Enddiastolische Dehnbarkeit des linken Ventrikels bei akuten Änderungen des arteriellen Systemdrucks. Pflügers Arch. Physiol.285, 355 (1965).
Benchimol, A., Y. Li, andG. Dimond, Cardiovascular dynamics in complete heart block at various heart rates. Effect of exercise at a fixed heart rate. Circulation30, 542 (1964).
Bevegård, S., Observations on the effect of varying ventricular rate on the circulation at rest and during exercise in two patients with an artificial pacemaker. Acta med. Scand.172, 615 (1962).
Bevegård, S., A. Holmgren, andB. Jonsson, Circulatory studies in well trained athletcs at rest and during heavy exercise, with special reference to stroke volume and the influence of body position. Acta physiol. scand.57, 26 (1963).
Blinks, J. R. andJ. Koch-Weser, Analysis of the effects of changes in rate and rhythm upon myocardial contractility. J. Pharmacol. exper. Ther.134, 373 (1961).
Brady, A. J., Development of tension in cardiac muscle. Pharmacology of cardiac function, p. 15 (London 1964).
Braunwald, E., A. Goldblatt, D. C. Harrison, andD. T. Mason, Studies on cardiac dimensions in intact unanesthesized man: III. Effects of muscular excreise. Circulation Research13, 460 (1963).
Braunwald, E., E. H. Sonnenblick, J. Ross, G. Glick, andSt. E. Epstein, An analysis of the cardiac responses to exercise. Suppl. I to Circul. Res.20/21, 44 (1967).
Braunwald, E., J. R. Ross, P. L. Frommer, J. F. Williams, E. Sonnenblick, andJ. H. Gault, Clinical observations on paired electrical stimulation of the heart. Effects on ventricular performance and heart rate. Amer. J. Med.37, 700 (1964).
Braunwald, E., J. Ross, E. H. Sonnenblick, P. L. Frommer, N. S. Braunwald, andA. G. Morrow, Slowing of heart rate, electroaugmentation of ventricular performance and increase of myocardial oxygen consumption produced by paired electrical stimulation. Bull. New York Acad. Med.41, 481 (1965).
Bruce, Th. A., C. B. Chapman, O. Baker, andJ. N. Fisher, The role of autonomic and myocardial factors in cardiac control. J. clin. invest.42, 721 (1963).
Brutsaert, D., Influence of different stimulation frequencies on the cardiac output at rest and during moderate exercise in dogs with chronic atrioventricular heart block. Acta Cardiologica20, 469 (1965).
Cerretelli, P., J. Pijper, F. Mangili, F. Cuttica, andB. Ricci, Circulation in exercising dogs. J. appl. Physiol.19, 29 (1964).
Chapman, C. B., J. N. Fisher, andB. J. Sproule, Behaviour of stroke volume at rest and during exercise in human beings. J. Clin. Invest.39, 1208 (1960).
Cranefield, P. F., The force of contraction of extrasystoles and the potentiation of force of the postextrasystolic contraction: A historical review. Bull. N. Y. Acad. Med.41, 419 (1965).
Cranefield, P. F., B. J. Scherlag, B. K. Yeh, andB. F. Hoffman, Treatment of acute cardiac failure by maintained postextrasystolic potentiation. Bull. N. Y. Acad. Med.40, 903 (1964).
Donald, E. D. andJ. T. Shepherd, Response to exercise in dogs with cardiac denervation. Amer. J. Physiol.205, 393 (1963).
Downing, S. E. andE. H. Sonnenblick, Cardiac muscle mechanics and ventricular performance: force and time parameters. Amer. J. Physiol.207, 705 (1964).
Edman, K. A. P., D. W. Grieve, andE. Nilsson, Studies of the excitationcontraction mechanism in the skeletal muscle and the myocardium. Pflügers Arch. ges. Physiol.290, 320 (1966).
Ekelund, L. G. andA. Holmgren, Central hemodynamics during exercise. Suppl. I to Circul. Res.20/21, 33 (1967).
Epstein, S. E., B. F. Robinson, R. L. Kahler, andE. Braunwald, Effects of beta-adrenergic blockade on the cardiac response to maximal and submaximal exercise in man. J. Clin. Invest.44, 1745 (1965).
Feigl, E. O., Effects of stimulation frequency on myocardial extensibility. Circul. Res.20, 447 (1967).
Fisher, V. J., R. J. Lee, A. M. Marlon, andF. Kavaler, Paired electrical stimulation and the maximal contractile response of the ventricle. Circul. Res.20, 520 (1967).
Fleckenstein, A., H., Kammermeier, H. J. Döring undH. J. Freund, Zum Wirkungsmechanismus neuartiger Koronardilatatoren mit gleichzeitig Sauerstoff-einsparenden Myocardeffekten, Prenylamin und Iproveratril. Z. Kreislaufforschg.56, 716 (1967).
Frank, O., Die Wirkung von Digitalis (Helleborein) auf das Herz. Sitzber. Ges. Morph. u. Physiol.14, 14 (1898).
Gauer, O. H. andH. L. Thron, Postural changes in the circulation. Handbook of Physiology, Section2, Vol. III 2409 (1965).
Geiil, H., K. Graf undK. Kramer, Das Druck-Volumendiagramm des Kaltblüterherzens. Pflüg. Arch. Physiol.261, 270 (1955).
Gilmore, J. P., H. E. Cingolani, R. R. Taylor, andR. H. McDonald, Physical factors and cardiac adaption. Amer. J. Physiol.211, 1219 (1966).
Gilmore, J. P., H. E. Cingolani, R. R. Taylor, andW. J. Powell, Influence of ventrikular activation on ventrikular compliance. Amer. J. Physiol.211, 1227 (1966).
Glick, G., E. H. Sonnenblick, andE. Braunwald, Myocardial force-veloctiy studies in intact unanesthetized men. J. Clin. Invest.44, 978 (1965).
Glick, G., J. F. Williams, D. G. Harrison, A. G. Morrow, andE. Braunwald, Cardiac dimensions in intact unanesthetized man. VI. Effects of changes in heart rate. J. appl. Physiol.21, 947 (1966).
Graham, T. P., W. J. Powell, R. L. Clany, andJ. P. Gilmore, Characterization of the frequency-force relationship in the dog atrium in situ. Circul. Res.20, 338 (1967).
Hahn, N., H. Schaefer, andH. Weidinger, The differential quotient of QRS as a measure of the sympathetic tonization of the myocardium. Cardiologia48, 224 (1966).
Heppner, R. L., S. Weidmann, andE. H. Wood, Positive and negative inotropic effects by constant electric currents or current pulses applied during the cardiac action potential. Helv. Physiol. Acta24, C 94 (1966).
Hoffman, B. F., H. J. Bartelstone, B. J. Scherlag, Der Kontraktionskraft und Verlangsamung der Frequenz des Herzens. Anaesthesiologie und Wiederbelebung15, 123 (1966). andP. F. Cranefield, Effects of postextrasystolic potentiation on normal and failing hearts. Bull. N. Y. Acad. Med.41, 498 (1965).
Hoffman, B. F., E. Bindler, andE. E. Suckling, Postextrasystolic potentiation of contraction in cardiac muscle. Amer. J. Physiol.185, 95 (1956).
Holmgren, A., Circulatory changes during muscular work in man. Scand. J. Clin. Lab. invest. Suppl.24, 1–96 (1956).
Jacob, R., a) Kontraktions- und Relaxationsphasen des Warmblüterherzens in situ bei normaler und herabgesetzter Kontraktilität; b) Druck-Volumen-Zeitbeziehungen im Tierexperiment, in:Reindell, H., J. Keul u.E. Doll, „Herzinsuffizienz, Pathophysiologie und Klinik”. Hinterzarten 1967 (Georg Thieme Stuttgart 1968).
Jacob, R. undK. H. Weigand, Die endsystolischen Druck-Volumenbeziehungen als Grundlage einer Beurteilung der Kontraktilität des linken Ventrikels in situ Pflügers Arch. ges. Physiol.289, 37 (1966).
Jacob, R., G. Kissling, E. E. Ohnhaus undJ. Segarra-Domenech, Kontraktilitätssteigerung des nicht hypodynamen Herzens durch postextrasystolische Potentiation. 32. Tagg. Dtsch. Physiol. Ges. Berlin 1966. Pflügers Arch. Physiol.291, 11 (1966).
Jacob, R., G. Kissling, E. E. Ohnhaus, U. Peiper undJ. Segarra-Domenech, Die „Kontraktilität” des suffizienten Herzens unter rechtsventrikulärem Schrittmacherantrieb. Arch. Kreislaufforschg.54, 192 (1967).
Kaufmann, R., A. Fleckenstein undH. Antoni, Ursache und Auslösungsbedingungen von Myocard-Kontraktionen ohne reguläres Aktionspotential. Arch. Ges. Physiol.278, 435 (1963).
Kavaler, F., V. J. Fisher, andJ. H. Stuckey, The potentiated contraction and ventricular “contractility”. Bull. N. Y. Acad. Med.41, 592 (1965).
Kerth, W. J. andJ. J. Kelly, Experience with paired pacing in experimental canine heart failure. Bull. N. Y. Acad. Med.41, 646 (1965).
Koch-Weser, J., Potentiation of myocardial contractility by continual premature extraactivations. Circul. Res.18, 330 (1966).
Köhler, R., W. Rutishauser, M. Gander undI. Babotai, Veränderungen der Dynamik des linken Ventrikels des Hundes unter paariger Stimulation vor und nach Beta-Blockade. Cardiologia (Basel)49, 135 (1966).
Langendorff, O., Über elektrische Reizung des Herzens. Arch. Physiol. (Arch. Anat. Physiol., Phys. Abt.) 284 (1885).
Lopez, J. F., Elelist, A., andL. N. Katz, Reducing heart rate of the dog by electrical stimulation. Circul. Res.15, 414 (1964).
Marshall, R. J. andJ. T. Shepherd, Exercise and the Circulation. Circul.27, 323 (1963).
Meijler, F. L. andD. Durrer, Physiological and clinical aspects of paired stimulation. Bull. N. Y. Acad. Med.41, 575 (1965).
Miller, E., W. L. Gleason, R. E. Whalen, J. J. Morris, andH. D. McIntosh, Effect of ventricular rate on the cardiac output in the dog with chronic heart block. Circul. Res.10, 658 (1962).
Mitchell, J. H., B. J. Sproule, andC. B. Chapman, The physiological meaning of the maximal oxygen intake test. J. clin. Invest.37, 538 (1958).
Musshoff, K., H. Reindell, H. Steim undK. König, Die Sauerstoffaufnahme pro Herzschlag (O2-Puls) als Funktion des Schlagvolumens, der arteriovenösen Differenz, des Minutenvolumens und des Herzvolumens. Z. Kreislaufforschg.48, 255 (1959).
Niedergerke, R., Staircase phenomenon and the action of calcium on the heart. J. Physiol. (London)134, 569 (1956).
Noble, M. I. M., D. Trenchard, andA. Guz, Left ventricular cjection in conscious dogs: II. Determinants of stroke volume. Circul. Res.19, 148 (1966).
Reichel, H., Diskussionsbeitrag. Proc. of the Internat. Union of Physiological Sciences, 22. Internat. Congress, Leiden, Vol. I,, p. 167 (1962).
Reiter, M., Die Entstehung von „Nachkontraktionen” im Herzmuskel unter Einwirkung von Calcium und von Digitalisglykosiden in Abhängigkeit von der Reizfrequenz. Naunyn-Schmiedebergs Arch. exp. Path. Pharmakol.242, 497 (1962).
Ross, J., J. W. Linhart, andE. Braunwald, Effects of changing heart rate in man by electrical stimulation of the right atrium: Studies at rest, during exercise, and with isoproterenol. Circulation32, 549 (1965).
Ross, J., E. H. Sonnenblick, G. A. Kaiser, P. L. Frommer, andE. Braunwald, Electroaugmentation of ventricular performance and oxygen consumption by repititive application of paired electrical stimuli. Circul. Res.16, 332 (1965).
Rushmer, R. F., Constancy of stroke volume in ventricular responses to exertion. Amer. J. Physiol.196, 745 (1959).
Rushmer, R. F. andO. A. Smith, Cardiac control. Physiol. Reviews39, 41 (1959).
Rutishauser, W., M. Gander undM. Turina, Paarige Stimulation zur Verstärkung
Sarnoff, S. J., J. P. Gilmore, W. J. Daggett, P. B. Mansfield, M. L. Weisfeldt, andR. M. McDonald, Myocardial dynamics, contractility, O2 consumption and K+ balance during paired stimulation. Amer. J. Physiol.211, 376 (1966).
Sarnoff, S. J., J. H. Mitchell, J. P. Gilmore, andJ. P. Remensnyder, Homeometric autoregulation in the heart. Circulation Res.8, 1077 (1960).
Schaper, W. K. A., P. Lewi, andA. H. M. Jagenau, The determinantes of the rate of change of the left ventricular pressure (dP/dt). Arch. Kreislaufforschg.46, 27 (1965).
Schwarzkopf, H. J., J. Schaefer, W. Niedermayer, K. Held undF. Ulmer, Der Einfluß der gepaarten Elektrostimulation mit unterschiedlichen Reizfrequenzen auf die Kontraktionskraft des Hundeherzens in situ. Verh. Dtsch. Ges. Kreislaufforschg.33, 161 (Darmstadt 1967).
Shepherd, J. T., Behaviour of resistance and capacity vessels in human limbs. Suppl. I to Circul. Res.20/21 70 (1967).
Siebens, A. A., B. F. Hoffman, andP. F. Cranefield, Ventricular excitability and contractility. Amer. J. Physiol.183, 662 (1955).
Siegel, J. H. andE. H. Sonnenblick, Isometric timetension relationships as an index of myocardial contractility. Circul. Res.12, 597 (1965).
Singer, D. H., G. Galst, andM. L. Wagner, Effects of sustained paired stimulation of the heart in normal dogs and in dogs following coronary artery ligation. Bull. N. Y. Acad. Med.41, 652 (1965).
Sonnenblick, E. H., Force-velocity relations in mammalian heart muscle. Amer. J. Physiol.202, 931 (1962).
Sonnenblick, E. H., Determinants of active state in heart muscle: Force, velocity, instantaneous muscle length, time. Fed. Proc.24, 1296 (1965).
Sonnenblick, E. H., Diskussionsbemerkung. Bull. N. Y. Acad. Med.41, 721/722 (1965).
Sonnenblick, E. H., P. L., Frommer, andE. Braunwald, Electroaugmentation of human and cat papillary muscle produced by paired electrical stimulation. Bull. N. Y. Acad. Med.41, 554 (1965).
Sonnenblick, E. H., J. Ross, J. W. Covell, andE. Braunwald, Alterations in resting length-tension relations of cardiac muscle induced by changes in contractile force. Circul. Res.19, 980 (1966).
Sonnenblick, E. H., J. Ross, J. W. Covell, G. A. Kaiser, andE. Braunwald, Velocity of contraction as a determinant of myocardial oxygen consumption. Amer. J. Physiol.209, 919 (1965).
Stein, E., A. N. Damato, B. D. Kosowsky, S. H. Lau, andJ. W. Lister, The relation of heart rate to cardiovascular dynamics. Pacing by atrial electrodes. Circulation33, 525 (1966).
Tatooles, C. J. andN. S. Braunwald, The comparative hemodynamic effects of paired and single electrical stimulation of the heart: observation in animals with complete heart block and myocardial failure. Bull. N. Y. Acad. Med.41, 681 (1965).
Ullrich, K. J., R. Rieker undK. Kramer, Das Druckvolumendiagramm des Warmblüterherzens. Isometrische Gleichgewichtskurven. Pflügers Arch. Physiol.259, 481 (1954).
Wallace, A. G., W. G. Troyer, A. Lesage, andE. F. Zotti, Electrophysiologic effects of isoproterenol and beta blocking agents in awake dogs. Circul. Res.18, 140 (1966).
Warner, H. R. andA. F. Toronto, Regulation of cardiac output through stroke volume. Circul. Res. 8, 549 (1960).
Wetterer, E., Eine neue manometrische Sonde mit elektrischer Transmission. Z. Biol.101, 332 (1943).
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Mit Unterstützung der Deutschen Forschungsgemeinschaft. — Ein Teil der Ergebnisse wurde auf der 32. Tagung der Deutschen Physiologischen Gesellschaft (Berlin, 1966) (47) sowie anläßlich des Internat. Symposions über Herzinsuffizienz, Hinterzarten 1967 (45) vorgetragen.
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Jacob, R., Kissling, G. & Segarra-Domenech, J. Steigerungsfähigkeit von Kontraktionsgeschwindigkeit und Schlagvolumen durch inotrope Mechanismen beim intakten Herzen in situ. Archiv für Kreislaufforschung 57, 291–323 (1968). https://doi.org/10.1007/BF02119483
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DOI: https://doi.org/10.1007/BF02119483