Summary
When human recombinant interferon-α2 diluted in saline was injected s.c. into rabbits, the total amount recovered in thoracic lymph was less than 0.4%. Recoveries increased from 2- to 8-fold if interferon was injected in 4% albumin or with hyaluronidase, respectively. Albumin added to interferon acts as an interstitial fluid expander, thus favoring interferon absorption through lymphatics rather than blood capillaries. This strategy may increase the therapeutic index of interferon.
This is a preview of subscription content, log in via an institution to check access.
References
Billiau, A., Heremans, H., Ververken, D., van Damme, J., Carton, H., and De Somer, P., Arch. Virol.68 (1981) 19.
Cantell, K., and Pyhälä, L., J. infect. Dis.133, supp. (1976) A6.
Bocci, V., Pacini, A., Muscettola, M., Pessina, G.P., Paulesu, L., and Bandinelli, L., J. Interf. Res.2 (1982) 309.
Bocci, V., Mogensen, K.E., Muscettola, M., Pacini, A., Paulesu, L., Pessina, G.P., and Skiftas, S., J. Lab. clin. Med.101 (1983) 857.
Bocci, V., Pacini, A., Bandinelli, L., Pessina, G.P., Muscettola, M., and Paulesu, L., J. gen. Virol.60 (1982) 397.
Bocci, V., Cancer Drug Del.1 (1984) 337.
Bocci, V., Immun. today6 (1985) 7.
Bocci, V., Proc. Symp. Interferons, October 1983, Kyoto, Japan. Ed. T. Kishida.
Langford, M.P., Weigent, D.A., Stanton, G.J., and Baron, S., in: Interferons, part A, p. 339. Ed. S. Pestka. Academic Press, New York 1983.
Author information
Authors and Affiliations
Additional information
This work was supported by Ministero Pubblica Istruzione and Progetto Finalizzato Oncologia, contract No. 84.00461.44, CNR, Roma.
Rights and permissions
About this article
Cite this article
Bocci, V., Muscettola, M., Grasso, G. et al. The lymphatic route. 1) Albumin and hyaluronidase modify the normal distribution of interferon in lymph and plasma. Experientia 42, 432–433 (1986). https://doi.org/10.1007/BF02118644
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02118644