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The cellular immune response to heat shock proteins

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  • Heat Shock Proteins
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Abstract

T lymphocytes, which are central to almost every immune response, frequently recognize microbial hsp60. Such cells could provide an early defense mechanism against pathogenic microbes. However, T cells also recognize epitopes of hsp60 shared by microbe and host. Not only conventional α/β T cells respond to hsp60; γ/δ T cells do so, as well. In fact, certain γ/δ T cells seem to have a particular preference for this molecule. Recognition of stressed host cells expressing hsp60 could facilitate the scavenger function of the T cell system. On the other hand, such recognition could be involved in autoimmune disease.

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  1. Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900, Ulm, Germany

    S. H. E. Kaufmann

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Kaufmann, S.H.E. The cellular immune response to heat shock proteins. Experientia 48, 640–643 (1992). https://doi.org/10.1007/BF02118309

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