References
Aminoff D, Vorder Bruegge WF, Bell WC, Sarpolis K, Williams R (1979) Role of sialic acid in survival of erythrocytes in the circulation: Interaction of neuraminidase-treated and untreated erythrocytes with spleen and liver at the cellular level. Proc Natl Acad Sci USA 74: 1521
Atkinson JP, Frank MM (1977) Role of complement in the pathophysiology of hematologic disease. Prog Hematol 10: 211
Blanc C, Lopez Trascasa M, Sobel AT (1979) C4-dependent phagocytosis by human mononuclear cells. Vth European Complement workshop 1979. Abstracts
Borne AEGKr, von Dem, Helmerhorst FM, Leeuwen EF, van Pegels HG, Riesz E, Engelfriet CP (1980) Autoimmune thrombocytopenia: Detection of platelet autoantibodies with the suspension immunofluorescence test. Br J Haematol 45: 319
Borsos T, Rapp HJ (1965) Hemolysin titration based on fixation of the activated first component of complement: Evidence that one molecule of hemolysin suffices to sensitize an erythrocyte. J Immunol 95: 559
Chanarin I, James D, Stafford D, Tidmarsh E (1977) Platelet autoimmunity. Br J Haematol 37: 283
Chaplin H, Hoffmann NL (1982) Radioimmunoassay evaluation of anti-C3d reactivity in broad spectrum commercial antiglobulin reagents. Transfusion 22: 6
Chaplin H, Monroe MC, Lachmann PJ (1983) Further studies on the C3g component of the α2D fragment of human C3. Clin Exp Immunol 51: 639
Cheng CM, Hawiger J (1979) Affinity isolation and characterization of immunoglobulin G Fc fragment-binding glycoprotein human blood platelets. J Biol Chem 254: 2165
Chenoweth DE, Hugh TE (1979) Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes. Proc Natl Acad Sci USA 75: 3943
Cines DB, Schreiber AD (1979) Immune thrombocytopenia. Use of a Coomb's antiglobulin test to detect IgG and C3 on platelets. N Engl J Med 300: 106
Cines DB, Schreiber AD (1979) Effect of anti-P1A1 antibody on human platelets. I. The role of complement. Blood 53: 567
Coombs RRA, Mourant AE (1947) On certain properties of anti-sera prepared against human serum and its various protein fractions; their use in the detection of sensitization of human red cells with “incomplete” Rh antibody, and on the nature of this antibody. J Pathol Bacteriol 59: 105
Craddock CG Jr, Perry S, Lawrence JS (1960) The dynamics of leukopenia and leukocytes. Ann Intern Med 52: 281
Craddock PR, Fehr J, Dalmasso AP, Brigham KL, Jacob HS (1977) Hemodialysis leukopenia: pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. J Clin Invest 59: 879
Dacie JV (1975) Autoimmune hemolytic anemia. Arch Intern Med 135: 1293
Davis AE III, Kenney DM (1979) Properdin factor D: Effects or thrombin-induced platelet aggregation. J Clin Invest 64: 721
Dixon R, Rosse W, Ebbert L (1975) Quantitative determination of antibody in idiopathic thrombocytopenic purpura: Correlation of serum and platelet-bound antibody with clinical response. N Engl J Med 292: 230
de Gramont A, Kazatchkine MD, Maillet F, Blanche M, Debray J (1983) Hémoglobinurie paroxystique nocturne. Elevation des protéins de la voie alterne du complément. Nouv Presse Méd 12: 747
Edwards M, Nicholson-Weller A, Baker CJ, Kasper DL (1980) The role of specific antibody in alternative complement pathway mediated opsonophagocytosis of type III group streptococcus. J Exp Med 151: 1275
Ehlenberger AG, Nussenzweig V (1977) The role of membrane receptors for C3b and C3d in phagocytosis. J Exp Med 145: 357
Evans RS, Turner E, Bingham M (1967) Chronic hemolytic anemia due to cold agglutinins: the mechanism of resistance of red cells to C hemolysis by cold agglutinins. J Clin Invest 46: 1461
Eyster ME, Jenkins DE (1969) Erythrocyte-coating substances in patients with positive direct antiglobulin reactions. Am J Med 46: 360
Fearon DT (1979) Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane. Proc Natl Acad Sci USA 76: 5867
Fehr J, Jacob HS (1977) In vitro granulocyte adherence and in vivo margination: two associated complement-dependent functions. Studies based on the acute neutropenia of filtration leukophoresis. J Exp Med 146: 641
Fischer JT, Petz LD, Garratty G, Cooper NR (1974) Correlations between quantitative assay of redcell bound C3, serologic reactions, and hemolytic anemia. Blood 44: 359
Frank MM, Dourmashkin RR, Humphrey JJ (1970) Observations on the mechanism of immune hemolysis: Importance of immunoglobulin class and source of complement on the extent of damage. J Immunol 104: 1502
Frank MM, Lawley T, Hamburger MI, Brown EJ (1983) Immunoglobulin G Fe receptor-mediated clearance in autoimmune disease. Ann Intern Med 98: 206
Fruitstone MJ (1978) C3b-sensitized erythrocytes. Transfusion 18: 125
Ginsberg MH, Henson PM (1978) Enhancement of platelet response to immune complexes and IgG aggregates by lipid A rich bacterial lipopolysaccharides. J Exp Med 147: 207
Götze O, Müller-Eberhard HJ (1972) Paroxysmal nocturnal hemoglobinuria. Hemolysis by the C3 activator system. N Engl J Med 286: 180
Greenberg J, Packham MA, Cazenave J-P, Reimers H-J, Mustard JF (1975) Effects on platelet function of removal of platelet sialic acid and by neuraminidase. Lab Invest 32: 476
Greenberg JP, Packham MA, Guccione MA, Rand ML, Reimers H-J, Mustard JF (1979) Survival of rabbit platelets treated in vitro with chymotrypsin, plasmin, trypsin, or neuraminidase. Blood 53: 916
Hamm TH, Dingle JH (1939) Studies on destruction of red blood cells. II. Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria: Certain immunological aspects of the hemolytic mechanism with special reference to serum complement. J Clin Invest 18: 657
Handin RI, Stossel TP (1978) Effect of corticosteroid therapy on the phagocytosis of antibody-coated platelets by human leukocytes. Blood 51: 771
Handwerger BS, Kay NE, Douglas SD (1978) Lymphocyte-mediated antibody-dependent cytolysis: Role in immune hemolysis. Vox Sang 34: 276
Hänsch GM, Hammer CH, Vanguri P, Shin ML (1981) Homologous species restriction in lysis of erythrocytes by terminal complement proteins. Proc Natl Acad Sci USA 78: 5118
Harris JW (1956) Studies of mechanism of a drug-induced hemolytic anemia. J Lab Clin Med 47: 760
Hartmann RC, Jenkins DE, Arnold AB (1970) Diagnostic specificity of sucrose hemolysis test for paroxysmal nocturnal hemoglobinuria. Blood 35: 462
Hauch TW, Rosse WF (1977) Platelet-bound complement (C3) in immune thrombocytopenia. Blood 50: 1129
Henson PM, Ginsberg MH (1981) Immunological reactions of platelets. In: Gordon JI (ed) Platelets in biology and pathology 2. Elsevier, Amsterdam, p. 265
Hosea SW, Brown EJ, Hamburger MI, Frank MM (1981) Opsonic requirements for intravascular clearance after splenectomy. N Engl J Med 304: 245
Hughes-Jones NC, Gosh S (1981) Anti-D coated Rh-positive red cells will bind the first component of the complement pathway, C1q. FEBS Lett 128: 318
Hunt JS, Beck ML, Tegtmeier GE, Bayer WL (1982) Factors influencing monocyte recognition of human erythrocyte autoantibodies in vitro. Transfusion 22: 355
Iida K, Nussenzweig V (1981) Complement receptor is an inhibitor of the complement cascade. J Exp Med 153: 1138
Iida K, Mornaghi R, Nussenzweig V (1982) Complement receptors (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus. J Exp Med 155: 1427
Imbach P, Jungi TW (1983) Possible mechanisms of intravenous immumoglobulin treatment in childhood idiopathic thrombocytopenic purpura (ITP). Blut 46: 117
Inada S, Brown EJ, Gaither TA, Hammer CH, Takahashi T, Frank MM (1983) C3d receptors are expressed on human monocytes following in vitro cultivation. Proc Natl Acad Sci USA 80: 2351
Isenman DE, Dorrington KJ, Painter RH (1975) The importance of interchain disulfide bonds and the possible role of molecule flexibility in the interaction between IgG and complement. J Immunol 114:1726
Jack RM, Fearon DT (1983) Cytoskeletal attachment of Cab receptor (C3bR) and reciprocal coredistribution with Fc receptor (FcR) on human polymorphonuclear leukocytes (PMN). Abstr Fed Proc 42: 1235
Jaffe CJ, Atkinson JP, Frank MM (1976) The role of complement in the clearance of cold agglutinin sensitized erythrocytes in man. J Clin Invest 58: 942
Jaffe CJ, Vierling JM, Jones AE, Lawley TJ (1978) Receptor specific clearance by the reticuloendothelial system in chronic liver disease. J Clin Invest 62: 1069
Kayser W, Mueller-Eckhardt C, Budde V, Schmidt RE (1981) Complement-fixing platelet autoantibodies in autoimmune thrombocytopenia. Am J Hematol 11: 213
Kayser W, Mueller-Eckhardt C, Bhakdi S, Ebert K (1983) Platelet-associated complement C3 in thrombocytopenic states. Br J Haematol 54: 353
Kazatchkine MD, Fearon DT, Austen KF (1979) Human alternative complement pathway: Membrane-associated sialic acid regulates the competition between B andβIH for cell-bound C3b. J Immunol 122: 75
Kazatchkine MD, Nydegger UE (1982) The human alternative complement pathway: Biology and immunopathology of activation and regulation. Prog Allergy 30: 193
Kelton J, Meltzer D, Moore J, Giles AR, Wilson WE, Barr R, Hirsh J, Neame PB, Powers PJ, Walker I, Bianchi F, Caster CJ (1981) Drug-induced thrombocytopenia is associated with increased binding of IgG to platelets both in vivo and in vitro. Blood 58: 524
Kelton J, Neame PB, Gauldie J, Hirsh J (1979) Elevated platelet-associated IgG in the thrombocytopenia of septicemia. N Engl J Med 300: 760
Kenney DM, Davis AE III (1981) Interactions of the alternative complement pathway proteins factor D andβ1H, with human blood platelets. In: Bing DH, Rosenbaum RH (eds) Plasma and cellular modulatory proteins. Center Blood Research, Boston, p 215
Kernoff LM, Blake KCH, Shackleton D (1980) Influence of the amount of platelet-bound IgG on platelet survival and site of sequestration in autoimmune thrombocytopenia. Blood 55: 730
Lalezari P (1982) Neutrophil antigens immunology and clinical implications. In: Greenwalt T, Jamieson GA (eds) The granulocyte: Function and clinical utilization. Alan R. Liss, New York, p 209
Lalezari P, Jiang AF, Yegen L, Santorieneou M (1975) Chronic autoimmune neutropenia due to anti-NA2 antibody. N Engl J Med 293: 744
Lalezari P, Louie JE, Fadlallah N (1982) Serologic profile of alphamethyldopa-induced anemia: correlation between cell-bound IgM and hemolysis. Blood 59: 61
Lambré CR, Kazatchkine MD, Maillet F, Thibon M (1982) Guinea pig erythrocytes after their contact with influenza virus, acquire the ability to activate the human alternative complement pathway through virus-induced desialation of the cells. J Immunol 128: 629
Law SK, Levine RP (1977) Interaction between the third complement protein and cell surface macromolecules. Proc Natl Acad Sci USA 74: 2701
Logue GL, Rosse WF, Gockerman JP (1973) Measurement of the third component of complement bound to red blood cells in patients with the cold agglutinin syndrome. J Clin Invest 52: 493
Loos M (1982) The classical complement pathway: mechanism of activation of the first component by antigen-antibody complexes. Prog Allergy 30: 135
Luner SJ, Szlarek D, Knox RJ, Seaman GVF, Josefowicz JY, Ware BR (1977) Red cell charge is not a function of cell age. Nature 269: 719
Lutz HU (1981) Elimination alter Erythrozyten aus der Zirkulation. Freilegung eines Zellalterspeziischen Antigens auf alternden Erythrozyten. Schweiz Med Wochenschr 111: 1507
Maillet F, Kazatchkine MD, Keiffer N (1983) Lysis of human platelets in autologous serum after their contact with influenza virus. V International Congress of Immunology. Abstracts
McMillan R, Martin M (1981) Fixation of C3 to platelets in vitro by antiplatelet antibody from patients with immune thrombocytopenic purpura. Br J Haematol 47: 251
Medof ME, Iida K, Mold C, Nussenzweig V (1982) Unique role of the complement receptor CR1 in the degradation of C3b associated with immune complexes. J Exp Med 156: 1739
Medof ME, Lam T, Prince GM, Mold C (1983) Requirement for human red blood cells in inactivation of C3b in immune complexes and enhancement of binding to spleen cells. J Immunol 130: 1336
Miescher PA (1955) Leucopénies et agranulocytoses d'origine immunologique. Sang 26: 71
Miescher PA, Miescher A (1978) Immunologic drug-induced blood dyscrasias. Klin Wochenschr 56: 1
Moore FD Jr, Fearon DT, Austen KF (1981) IgG on mouse erythrocytes augments activation of the human alternative complement pathway by enhancing deposition of C3b. J Immunol 126: 1805
Morse EE, Zinkham WH, Jackson DP (1966) Thrombocytopenic purpura following rubella infection in children and in adults. Arch Intern Med 117: 573
Mueller-Eckhardt Ch (1977) Idiopathic thrombocytopenic purpura (ITP): clinical and immunologic considerations. Semin Thromb Hemostas 3: 125
Mueller-Eckhardt C, Kayser W, Mersch-Baumert K, Mueller-Eckhardt G, Breidenbach M, Kugel H-G, Graubner M (1980) The clinical significance of platelet-associated IgG: A study on 298 patients with various disorders. Br J Haematol 46: 123
Myers TJ, Kim BK, Steiner M, Baldini MG (1982) Platelet-associated complement C3 in immune thrombocytopenic purpura. Blood 59: 1023
Myllilä G, Vaheri A, Vesikari T, Penttinen K (1969) Interaction between human blood platelets, viruses and antibodies. Clin Exp Immunol 4: 323
Nel JD, Stevens K (1980) A new method for the simultaneous quantitation of platelet-bound immunoglobulin (IgG) and complement (C3) employing an enzyme-linked immunosorbent assay (ELISA) procedure. Br J Haematol 44: 281
Newman SL, Musson RA, Henson PM (1980) Development of functional complement receptors during in vitro maturation of human monocytes into macrophages. J Immunol 125: 2236
Nydegger UE, Miescher PA (1975) Immunological mechanisms in drug-induced blood dyscrasias. J Clin Pathol [Suppl] 28: 46
Nydegger UE, Fearon DT, Austen KF (1978) Amosomal locus regulates inverse relationship between sialic acid content capacity of mouse erythrocytes to activate the human alternative complement pathway. Proc Natl Acad Sci USA 75: 6078
Okada H, Tanaka H, Okada N (to be published) Prevention of complement activation on the homologous cell membrane of nucleated cells as well as erythrocytes.
Packman CH, Rosenfeld SL Jenkins DE Jr, Thiems PA, Leddy JP (1979) Complement lysis of human erythrocytes differing susceptibility of two types of paroxysmal nocturnal hemoglobinuria cells to C5b-9. J Clin Invest 64: 428
Parker CJ, Baker PJ, Rosse WF (1982) Increased enzymatic activity of the alternative pathway convertase when bound to the erythrocytes of paroxysmal nocturnal hemoglobinuria. J Clin Invest 69: 337
Perrin LH, Joseph BS, Cooper NR, Oldstone MBA (1976) Mechanism of injury of virus-infected cells by antiviral antibody and complement. Participation of IgG F(ab)2 in alternative complement pathway activation. J Exp Med 143: 1027
Petz LD (1980) Drug-induced immune hemolytic anemia. Clin Haematol 9: 455
Platts-Mills TAE, Ishizaka K (1974) Activation of the alternative pathway of human complement by rabbit cells. J Immunol 113: 348
Polley MJ, Nachmann RL (1981) The human complement system in thrombin-mediated platelet function. In: Gordon JI (ed) Platelets in biology and pathology 2. Elsevier, Amsterdam, p 309
Rand ML, Greenberg JP, Packham MA, Mustard JF (1981) Density and subpopulations of rabbit platelets: Size, protein, and sialic acid content, and specific radioactivity charges following labeling with35S-sulfate in vivo. Blood 57: 741
Ronault TA, Rosse WF, Bell S, Shelburne J (1978) Differences in the terminal steps of complement lysis of normal and paroxysmal nocturnal hemoglobinuria red cells. Blood 51: 325
Rosenfeld SI, Packman CH, Leddy JP (1983) Inhibition of the lytic action of cell-bound terminal complement components by human high density lipoproteins and apoproteins. J Clin Invest 71: 795
Rosse WF (1973) Variations in the red cells in paroxysmal nocturnal hemoglobinuria. Br J Haematol 24: 327
Rosse WF, Logue GL, Adams J, Crookston JH (1974) Mechanisms of immune lysis of the red cells in hereditary erythroblastic multinuclearity with a positive acidified serum test and paroxysmal nocturnal hemoglobinuria. J Clin Invest 53: 31
Rustagi PK, Kazie MS, Logue GL (1982) Activation of human complement by immunoglobulin G antigranulocytic antibody. J Clin Invest 70: 1137
Salama A, Bhakdi S, Mueller-Eckhardt C, Kayser W (1983) Deposition of the terminal C5b-9 complement complex on erythrocytes by human red cell autoantibodies. Br J Haematol 55: 155
Schmid FR, Roitt IM, Rocha MJ (1970) Complement fixation by a two component antibodysystem: Immunoglobulin G and immunoglobulin M antiglobulin (rheumatoid factor). Paradoxical effect related to immunoglobulin G concentration. J Exp Med 132: 673
Schopf RE, Hammann KP, Schreiner O, Lemmel EM, Dietrich MP (1982) Activation of human monocytes by both humanβ1H and C3b. Immunology 46: 307
Schreiber AD (1977) An experimental model of immune hemolytic anemia, pp 211–213 in Frank, M.M. (moderator): Pathophysiology of immune hemolytic anemia. Ann Intern Med 87: 210
Shulman NR (1958) Immunoreaction involving platelets. I. A steric and kinetic model for formation of a complex from a human antibody, quinidine as a haptene and platelets, and for fixation of complement by the complex. J Exp Med 107: 665
Shulman NR, Sheagren JN (1970) Hematologic complication. In: Neva FA (ed) Malaria: Host defense mechanisms and complicators. Ann Intern Med 73: 295
Skubitz KM, Craddock PR (1981) Reversal of hemodialysis granulocytopenia and pulmonary leukostasis. A clinical manifestation of selective downregulation of granulocytes to C5a des arg. J Clin Invest 67: 1383
Spiegelberg HA (1974) Biological activities of immunoglobulins of different classes and subclasses. Adv Immunol 19: 259
Spycher MO, Gross B, Nydegger UE (1983) Die Bindung von IgG and Aggregaten davon an menschlichen Thrombozyten (Tc) kann durch Verwendung von Deoxyglucose und Antimycin A zur Sättigung gebracht werden. Schweiz Med Wochenschr 113: 1469
Valone FH, Austen KF, Götze EJ (1979) Identification of the platelet activating activity in rheumatoid symonical fluid as an intermediate molecular weight, complex of IgG. J Immunol 122: 703
Van Oss CJ, Absolom DR (1983) Zeta potentials, van der Waals forces and hemagglutination. Vox Sang 44: 183
Veenhoven WA, van der Schans GS, Nieweg HO (1980) Platelet antibodies in idiopathic thrombocytopenia purpura. Clin Exp Immunol 39: 645
Wells JV, Ries CA (1980) Hematologic diseases. Fudenberg HH, Sites DP, Caldwell JL, Wells JV (eds) Basic and clinical immunology, 3rd edn. Lange Medical Publications, p 473
Woodruff AW, Ansdell VE, Pettitt LE (1979) Cause of anemia in malaria. Lancet 1: 1055
Yamamoto K, Gewurz H (1978) The complex of C5b and C6: Isolation, characterization, and identification of a modified form of C5b consisting of three polypeptide chains. J Immunol 120: 2008
Ziccardi RJ, Cooper NR (1976) Activation of C1r by proteolytic cleavage. J Immunol 116: 504
Ziccardi RJ (1983) The first component of human complement (C1): Activation and control. Springer Semin Immunopathol 6: 213–230
Zimmermann TS, Kolb WP (1976) Human platelet-initiated formation and uptake of the C5b-9 complex of human complement. J Clin Invest 57: 203
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Nydegger, U.E., Kazatchkine, M.D. The role of complement in immune clearance of blood cells. Springer Semin Immunopathol 6, 373–398 (1983). https://doi.org/10.1007/BF02116281
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DOI: https://doi.org/10.1007/BF02116281