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Treatment of osteopenia in children with insulin-dependent diabetes mellitus: The effect of 1α-hydroxyvitamin D3

  • Endocrinology
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Abstract

Twelve children (8 boys and 4 girls) with insulin-dependent diabetes mellitus (IDDM), aged 9–15 years, received 1α-hydroxyvitamin D3 (1α-OHD3) in a dose of 0.05 μg/kg per day for 1 year. Duration of disease varied between 2.8 and 9 years. Bone density was determined in the distal third of forearm using single photon absorptiometry, and was expressed as standard scores (±SD) with respect to sex- and agemateched controls. Bone density measurements and ultrasound studies of the kidneys were performed at 0,6 and 12 months. Serum calcium, ionized calcium, phosphorus, magnesium, creatinine, alkaline phosphatase, glycosylated haemoglobin in morning blood samples and urinary Ca, P, Mg, and hydroxyproline were regularly determined. One patient was excluded from the study because of hypercalciuria and one because of lack of compliance. Bone density increased significantly after 6 and 12 months of 1α-OHD3 administration (P=0.015,P<0.001 respectively). None of the biochemical parameters changed significantly.

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Abbreviations

1α-OHD 3 :

1α-hydroxyvitamin D3

1,25 (OH) 2D 3 :

1,25 dihydroxyvitamin D3

BD :

bone density

IDDM :

insulindependent diabetes mellitus

UCa/Ucr :

urinary calcium creatinine ratio

UMg/UCr :

urinary magnesium creatinine ratio

UOH-Pr/UCr :

urinary hydroxyproline creatinine ratio

UP/UCr :

urinary phosphorus creatinine ratio

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Authors and Affiliations

  1. Institute of Child Health, “Ag. Sophia” Children's Hospital, GR-11527, Athens, Greece

    A. Al-Qadreh, I. Voskaki, H. Athanasopoulou & E. Sarafidou

  2. Diabetes Centre, “P and A Kyriakou”, Children's Hospital, GR-11527, Athens, Greece

    C. Kassiou & C. S. Bartsocas

Authors
  1. A. Al-Qadreh
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  2. I. Voskaki
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  3. C. Kassiou
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  4. H. Athanasopoulou
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  5. E. Sarafidou
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  6. C. S. Bartsocas
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Al-Qadreh, A., Voskaki, I., Kassiou, C. et al. Treatment of osteopenia in children with insulin-dependent diabetes mellitus: The effect of 1α-hydroxyvitamin D3 . Eur J Pediatr 155, 15–17 (1996). https://doi.org/10.1007/BF02115619

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  • DOI: https://doi.org/10.1007/BF02115619

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