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Depigmentation and coat colour variegation in mice treated with 8-hydroxyquinoline

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  • Chimica, Biochimica, Biophysica
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Zusammenfassung

Die Melanogenese wird bei Mäusen durch 8-Hydroxychinolin selektiv gehemmt. Besonders bei behandelten weiblichen Tieren des Stammes C57BL entwickelt sich ein aussergewöhnliches Haarmuster mit abwechselnden schwarzen und weissen Streifen oder Kreisen. Diese reversible Wirkung wurde bei neugeborenen Mäusen oder nach Behandlung mit Cu-reaktiven Substanzen nicht beobachtet.

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Authors and Affiliations

  1. Department of Cancer Studies, University of Birmingham, The Medical School, Birmingham 15, England

    C. E. Searle

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  1. C. E. Searle
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Additional information

I wish to thank Professor D. G.Harnden and Dr.Mary Lyon for their interest and advice, and Mr. C. R.Richardson for technical assistance. The work was supported by the Birmingham Branch of the British Empire Cancer Campaign for Research.

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Searle, C.E. Depigmentation and coat colour variegation in mice treated with 8-hydroxyquinoline. Experientia 26, 944–945 (1970). https://doi.org/10.1007/BF02114119

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  • DOI: https://doi.org/10.1007/BF02114119

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