Abstract
Recovery phase infection patterns in 55 patients who had undergone autologous blood progenitor cell transplantation (ABPCT) were evaluated retrospectively. The results were compared to those obtained in a group of 41 patients who received autologous bone marrow transplantation (ABMT). Fever related to documented or suspected infection developed in 38 of 55 patients in the ABPCT group and in 37 of 41 in the ABMT group (p<0.05). The percentages of patients with positive blood cultures did not differ significantly (ABPCT, 8/55 vs. ABMT, 8/41, p>0.05). However, fewer acquired systemic fungal infections (1/55 vs. 5/41, p<0.05) as well as fewer days of antibiotic usage were observed in the ABPCT group.
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References
Watson JG: Problems of infection after bone marrow transplantation. Journal of Clinical Pathology 1986, 36: 683–692.
Meyers JD: Infection in bone marrow transplant recipients. American Journal of Medicine 1986, 81, Supplement 1A: 27–38.
Rhodes LE, van Saene HKF, White S, Fairclough S, Ball LM, Martin J: Microbial carriage, sepsis, infection and acute GVHD in the first 25 BMT at the Royal Liverpool Children's Hospital. Bone Marrow Transplantation 1993, 11: 261–269.
Kirk JL, Greenfield RA, Slease RB, Epstein RB: Analysis of early infectious complications after autologous bone marrow transplantation. Cancer 1988, 62: 2445–2450.
Kessinger A, Armitage JO, Landmark JD, Bierman PJ, Weisenburger DD: Reconstitution of human hematopoietic function with autologous cryopreserved circulating stem cells. Experimental Hematology 1986, 14: 192–196.
Korbling M, Dorken B, Ho AD, Pezzuto A, Hunstein W, Fliedner TM: Autologous transplantation of blood-derived hematopoietic stem cells after myeloablative therapy in a patient with Burkitt's lymphoma. Blood 1986, 67: 529–532.
To LB, Roberts MM, Haylock DN, Dyson PG, Branford AL, Thorp D, Ho JQK, Dart GW, Horvath N, Davy MLJ, Olweny CLM, Abdi E, Juttner CA: Comparison of hematological recovery times and supportive care requirements of autologous recovery phase peripheral blood stem cell transplants, autologous bone marrow transplants and allogeneic bone marrow transplants. Bone Marrow Transplantation 1992, 9: 277–284.
Iacone A, Pierelli L, Quaglietta AM, Nicolucci A, Menichella G, Di Bartolomeo P, De Laurenzi A, Floritoni G, Indovina A, Leone G, Majolino I, Montuoro A, Fioritoni G, Indovina A, Leone G, Majolino I, Montuoro A, Di Marzio A, Torlontano G: Survival after PBSC transplantation and comparison of engraftment speed with autologous and allogeneic marrow transplantation: results of a multicenter study. International Journal of Artificial Organs 1993, Supplement 16/S5: 45–50.
Pierelli L, Iacone A, Quaglietta AM, Nicolucci A, Menichella G, Benedetti Panici P, D'Antonio D, De Laurenzi A, De Rosa L, Fioritoni G, Indovina A, Leone G, Majolino I, Montuoro A, Scimé R, Torlontano G: Haemopoietic reconstitution after autologous blood stem cell transplantation in patients with malignancies: a multicentre retrospective study. British Journal of Haematology 1994, 86: 70–75.
Finegold SM, Baron EJ: Bailey and Scott's diagnostic microbiology. C.V. Mosby, St. Louis, MO, 1986.
D'Antonio D, Angelini A, Iacone A, Dragani A, Di Gianfilippo R, Accorsi P, Quaglietta A, Geraci L, Berardi A, Dell'Isola M, Buono M, Torlontano G: Rapid detection of cytomegalovirus with monoclonal antibody in blood component donors: a simple screening for hemotherapy in a bone marrow transplantation program. Haematologica 1988, 73: 495–497.
D'Antonio D, Pizzigallo E, Iacone A, Dell'Isola M, Fioritoni G, Betti S, Piergallini A, Di Gianfilippo R, Olioso P, Torlontano G: Occurrence of bacteraemia in haematologic patients. European Journal of Epidemiology 1992, 8: 687–692.
D'Antonio D, Iacone A, Fioritoni G, Di Bartolomeo P, Toriontano G: Patterns of infection in 41 patients with idiosyncratic drug-induced agranulocytosis. Annals of Haematology 1991, 63: 84–88.
D'Antonio D, Iacone A, Fioritoni G, Angelini A, Dragani A, Betti S, Di Bartolomeo P, Di Bartolomeo G, Accorsi P, Quaglietta AM, D'Arcangelo L, Piccolomini R, Torlontano G: Infection after autologous blood-derived stem cell transplantation. Haematologica 1990, 75, Supplement 1: 83–86.
Watanabe T, Takaue Y, Abe T, Matsunaga K, Saito S, Hirao A, Kawano Y, Hirose M, Ninomiya T, Yokobayashi A, Kuroda Y: Early infectious complications after peripheral blood stem cell autografts in children. Medical and Pediatric Oncology 1991, 19: 100–105.
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A.M. Quaglietta, G. Fioritoni, P. Di Bartolomeo, A. Piergallini, Dipartimento di Ematologia e della Trasfusione, Ospedale Civile Pescara; I. Majolino, A. Indovina, Divisione di Ematologia, Ospedale V. Cervello, Palermo; G. Menichella, Istituto di Semeiotica Medica, Università Cattolica del Sacro Cuore, Rome; L. De Rosa, A. Montuoro, A. Pescarollo, Divisione di Ematologia, Ospedale S. Camillo, Rome; G. Parruti, Consorzio Mario Negri Sud, Institute of Pharmacological Research, Chieti, Italy.
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D'Antonio, D., Iacone, A., Pierelli, L. et al. Patterns of recovery phase infection after autologous blood progenitor cell transplantation in patients with malignancies. Eur. J. Clin. Microbiol. Infect. Dis. 14, 552–556 (1995). https://doi.org/10.1007/BF02113440
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DOI: https://doi.org/10.1007/BF02113440