Summary
An experimental study in rats has been carried out with the aim of studying the scar formation over the spinal dura in the presence of fibrin glue. Although the main action of fibrin glue is the enhancement of wound healing by increasing the fibrous tissue, our present data suggest that this re-absorbable biomaterial diminishes the epidural scar formation, at least the first two weeks after laminectomy. This finding leads us to consider the use of fibrin glue over spinal duramater when it is likely that reoperation may become necessary in a short period of time after a laminectomy.
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References
Barbera J, González J, Esquerdo J, Broseta J, Barcia-Salorio JL (1978) Prophylaxis of the laminectomy membrane. An experimental study in dogs. J Neurosurg 49: 419–424
Benoist M, Ficat C, Baraf P, Cauchois J (1980) Postoperative lumbar epiduroarachnoiditis. Diagnostic and therapeutic aspects. Spine 5: 432–436
Brodsky AE (1976) Post-laminectomy and post-fusion stenosis of the lumbar spine. Clin Orthop 115: 130–139
Bryant MS, Bremer AM, Nguyen TQ (1983) Autogenic fat transplants in the epidural space in routine lumbar spine surgery. Neurosurgery 13: 367–370
Cabezudo JM, López A, Bacci F (1985) Symptomatic root compression by a free fat transplant after hemilaminectomy. J Neurosurg 63: 633–635
De Villers PD, Booysen EL (1976) Fibrous spinal stenosis: a report on 850 myelograms with a water-soluble contrast medium. Clin Orthop 115: 140–144
Gill GG, Sakovich L, Thompson E (1979) Pedicle fat grafts for the prevention of scar formation after laminectomy. An experimental study in dogs. Spine 4: 176–186
Jacobs RR, McClain O, Neff J (1980) Control of post laminectomy scar formation. An experimental and clinical study. Spine 5: 223–229
Keller JT, Dunsker SB, McWhorter JM, Ongkiko CM, Saunders MC, Mayfield FH (1978) The fate of autologous grafts to the spinal dura. An experimental study. J Neurosurg 49: 412–418
Kiviluoto O (1988) Use of free fat transplants to prevent epidural scar formation. An experimental study. Acta Orthop Scand [Suppl] 164: 3–75
Langenskiöld A, Kiviluoto O (1976) Prevention of epidural scar formation after operations on the lumbar spine by means of free fat transplants. Clin Orthop 115: 92–95
La Rocca H, McNab I (1974) The laminectomy membrane. Studies in its evolution, characteristics, and prophylaxis in dogs. J Bone Joint Surg [Br] 56 B: 545–550
Lee CK, Alexander H (1984) Prevention of postlaminectomy scar formation. Spine 9: 305–312
Martin-Ferrer S (1989) Failure of autologous fat grafts to prevent postoperative epidural fibrosis in surgery of the lumbar spine. Neurosurgery 24: 718–721
Nussbaum CE, McDonald JV, Baggs RB (1990) Use of vicryl (polyglactin 910) mesh to limit epidural scar formation after laminectomy. Neurosurgery 26: 649–654
Rossitch E Jr, Wilkins RH (1990) The use of fibrin glue in Neurosurgery. In: Wilkins RH, Rengachary SS (eds) Neurosurgery update I. McCraw Hill, New York, pp 195–196
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Vaquero, J., Arias, A., Oya, S. et al. Effect of fibrin glue on postlaminectomy scar formation. Acta neurochir 120, 159–163 (1993). https://doi.org/10.1007/BF02112036
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DOI: https://doi.org/10.1007/BF02112036