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Prospective study of drug-resistant tuberculosis in a spanish urban population including patients at risk for HIV infection

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Abstract

From January 1988 to October 1992, the primary resistance to first-line antituberculous drugs in 501 tuberculous patients was evaluated prospectively. Three-hundred and seventeen patients were HIV-negative and 184 were HIV-positive; these patients had several different clinical forms of tuberculosis. Moreover, the acquired resistance to antituberculous drugs was studied in 295 non-AIDS patients and in 42 AIDS patients with evidence of antecedent tuberculosis treatment. The data indicated that during these five years there was no consistent and clear-cut trend toward greater frequency of primary drug resistance to any of the first-line antituberculous drugs. Primary drug resistance in HIV-positive patients (7.1 %) did not differ significantly (p>0.05) from that found in HIV-negative patients (8.2 %). Among HIV-positive patients, the acquired drug resistance pattern was similar to that detected in HIV-negative patients although the frequency of resistance in the former (69 %) was significantly higher (p<0.01). During the study, resistance to isoniazid was almost constant in the acquired-resistance cases and was frequently associated with resistance to other drugs. Furthermore, the acquired resistance to isoniazid was often of a higher level (1 to 10 mg/l) than the primary resistance (0.2 mg/l), and those strains were usually catalase and peroxidase negative.

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Authors and Affiliations

  1. Microbiology Laboratory, Sta. Cruz and San Pablo Hospital, Barcelona, Spain

    V. Ausina

  2. Microbiology Laboratory, Germans Trias i Pujol University Hospital, Carretera de Canyet s/n, 08916, Badalona, Spain

    V. Ausina, N. Riutort, B. Viñado, J. M. Manterola, L. Matas & M. Giménez

  3. Department of Pneumology, Germans Trias i Pujol University Hospital, Carretera de Canyet s/n, 08916, Badalona, Spain

    J. Ruiz Manzano

  4. Department of Paediatrics, Germans Trias i Pujol University Hospital, Carretera de Canyet s/n, 08916, Badalona, Spain

    C. Rodrigo

  5. Internal Medicine Service, Germans Trias i Pujol University Hospital, Carretera de Canyet s/n, 08916, Badalona, Spain

    J. Tor

  6. Epidemiology Unit, Germans Trias i Pujol University Hospital, Carretera de Canyet s/n, 08916, Badalona, Spain

    J. Roca

Authors
  1. V. Ausina
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  2. N. Riutort
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  3. B. Viñado
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  4. J. M. Manterola
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  5. J. Ruiz Manzano
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  6. C. Rodrigo
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  7. L. Matas
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  8. M. Giménez
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  9. J. Tor
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Ausina, V., Riutort, N., Viñado, B. et al. Prospective study of drug-resistant tuberculosis in a spanish urban population including patients at risk for HIV infection. Eur. J. Clin. Microbiol. Infect. Dis. 14, 105–110 (1995). https://doi.org/10.1007/BF02111867

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