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Multidrug resistance and P-glycoproteins in parasitic protozoa

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Abstract

Drug resistance has emerged as a devasting impediment to the treatment and control of diseases of parasitic origin. The underlying mechanisms that contribute to this drug resistance in field isolates, however, are poorly understood. Members of the P-glycoprotein gene (pgp) family have been identified, cloned, and sequenced inPlasmodia, Leishmania, andEamonteba, and variations inpgp copy number and/or expression have been implicated as a basis for drug resistance in each of these genera. The spectrum of drugs to which parasitic protozoa containing amplifiedpgp genes and/or transcripts are refractory range from a phenotype similar to that observed with multidrug-resistant mammalian cells to those that are completely distinct. The availability of molecular probes topgp genes provides valuable reagents to dissect the role ofpgp gene amplification and overexpression in mediating drug resistance in parasitic protozoa and to determine the physiological function of P-glycoproteins in this clinically consequential group of human pathogens.

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  1. Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, 97201-3098, Portland, Oregon

    Buddy Ullman

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Ullman, B. Multidrug resistance and P-glycoproteins in parasitic protozoa. J Bioenerg Biomembr 27, 77–84 (1995). https://doi.org/10.1007/BF02110334

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  • DOI: https://doi.org/10.1007/BF02110334

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