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The effect of intraperitoneal colchicine on the formation of peritoneal adhesions in the rat

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Summary

A double blind study was carried out to determine the effect of colchicine on the formation of intraperitoneal adhesions in the rat. Adhesions were produced by a standard method in 92 rats. The animals were then divided at random into two groups. One group (47 rats) was treated with intraperitoneal colchicine, whilst the other, the control group (45 rats) was treated with intraperitoneal normal saline in the same volume, frequency and duration. Four weeks later the animals were killed for assessment and measurement of adhesions. Two kinds of adhesions were found.

1. “Surface adhesion” — consisting of two serosal surfaces attached together; their area was significantly smaller (p < 0.00003), and their number was lower (p < 0.03) in the colchicine group than in the control group.

2. “Filamentous adhesions” — thin, elastic cords connecting omentum or pelvic fat bodies to other viscera; there was no significant difference in their number between the colchicine and the control group.

We concluded that post-operative treatment with colchicine reduces the formation of intraperitoneal adhesions in the rat.

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Authors and Affiliations

  1. Dept. of Obstetrics and Gynecology, Rothschild University Hospital, Technion, Israel Institute of Technology, Faculty of Medicine, Haifa, Israel

    I. Shapiro, M. Granat & M. Sharf

Authors
  1. I. Shapiro
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  2. M. Granat
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  3. M. Sharf
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Additional information

Supported by Grant No. 180-224 from the Technion Research Fund

Presented in part at the World Congress of Gynecology and Obstetrics, Tokyo, Japan, October 25–31, 1979

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Shapiro, I., Granat, M. & Sharf, M. The effect of intraperitoneal colchicine on the formation of peritoneal adhesions in the rat. Arch. Gynecol. 231, 227–233 (1982). https://doi.org/10.1007/BF02110122

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  • DOI: https://doi.org/10.1007/BF02110122

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