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Role of endogenous hypergastrinemia in regenerating endocrine pancreas after partial pancreatectomy

  • Pancreatic And Biliary Disorders
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Abstract

We studied the possible role of endogenous gastrin in the regenerating pancreas. Male Wistar rats underwent sham operation or 90% partial pancreatectomy (Px). Lansoprazole (30 mg/kg body wt), a proton pump inhibitor (PPI), was given p.o. for 3 weeks after surgery. Plasma glucose levels were higher in Px rats than in shams. Lansoprazole lowered plasma glucose levels in the Px rats. In addition, integrated insulin secretion during an oral glucose tolerance test (2 g/kg body wt) was significantly (p < 0.01) higher in lansoprazole-treated Px rats than in control Px rats, while lansoprazole did not affect insulin secretion in shams. Fasting serum gastrin levels were higher (p < 0.01) in lansoprazole-treated animals than in controls both in sham rats and in Px rats. Furthermore, lansoprazole increased the pancreas weight per body weight and elevated the insulin content of the pancreas in Px rats. These results suggest that endogenous hypergastrinemia has a trophic effect on endocrine pancreas during regenerating processes and that administration of PPI may be clinically beneficial to the remnant pancreas after pancreatectomy if the whole stomach is preserved.

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Authors and Affiliations

  1. Department of Clinical Nutrition, Suzuka University of Medical Science and Technology, 510-02, Mie, Japan

    Gang Xu MD, Shoichiro Sumi MD, Makoto Koike MD, Keiichiro Tanigawa MD, Yoshinori Nio MD & Katsuhiro Tamura MD

  2. First Department of Surgery, Shimane Medical University, 693, Izumo, Japan

    Gang Xu MD, Shoichiro Sumi MD, Makoto Koike MD, Keiichiro Tanigawa MD, Yoshinori Nio MD & Katsuhiro Tamura MD

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  1. Gang Xu MD
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  2. Shoichiro Sumi MD
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Xu, G., Sumi, S., Koike, M. et al. Role of endogenous hypergastrinemia in regenerating endocrine pancreas after partial pancreatectomy. Digest Dis Sci 41, 2433–2439 (1996). https://doi.org/10.1007/BF02100139

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  • DOI: https://doi.org/10.1007/BF02100139

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