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Die Resistenz des Mycobacterium tuberculosis gegen Ethionamid, Thiosemicarbazon und Isoxyl und ihre Beziehungen zueinander

Resistance of mycobacterium tuberculosis to ethionamide, thiacetazone and isoxyl and their relations to each other

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Beiträge zur Klinik und Erforschung der Tuberkulose und der Lungenkrankheiten Aims and scope Submit manuscript

Zusammenfassung

An Stämmen von 522 Lungentuberkulösen wurde in 1596 Testungen die Empfindlichkeit gegen Isoxyl, Thiosemicarbazon und Ethionamid gleichzeitig geprüft. In diesem Routinematerial betrug die Häufigkeit einer Thiosemicarbazonresistenz 8,2%, der Isoxylresistenz 10,1% und der Ethionamidresistenz 6,5%. Die Kreuzresistenz zwischen Thiosemicarbazon und Ethionamid ist sehr häufig. In 75% war die Isoxylresistenz mit einer Thiosemicarbazonresistenz gekoppelt. Eine primäre Resistenz gegen Isoxyl wurde in 3,5%, eine primäre Thiosemicarbazonresistenz in 1,5% beobachtet. Von den isoxylresistenten Stämmen waren 52,8% auch gegen Thiosemicarbazon und Ethionamid, weitere 22,6% nur gegen Thiosemicarbazon resistent. Eine Kreuzresistenz zwischen Isoxyl und Ethionamid wurde nur dann gefunden, wenn gleichzeitig auch eine Thiosemicarbazonresistenz bestand. Eine durch Isoxylbehandlung ausgelöste Isoxylresistenz kann von einer Thiosemicarbazonkreuzresistenz begleitet sein. Sie scheint jedoch nicht eine gekreuzte Ethionamidresistenz im Gefolge zu haben. Die Bedeutung dieser Feststellungen für die klinische und ambulante Chemotherapie wird erörtert.

Summary

In simultaneous examinations of sensitivity to Isoxyl, Thiacetazone and Ethionamide in 1596 samples of strains of 522 tuberculous patients we found a frequency of resistance to Thiacetazone in 8,2%, to Isoxyl in 10,1% and to Ethionamide in 6,5% of samples. Cross resistance between Thiacetazone and Ethionamide occurs frequently. In 75% the resistance to Isoxyl was connected with someone to Thiacetazone. Primary resistance to Isoxyl was seen in 3,5%, to Thiacetazone in 1,5%. 52,8% of the strains resistant to Isoxyl were also resistant to Thiacetazone and Ethionamide, 22,6% only to Thiacetazone. Cross resistance between Isoxyl and Ethionamide was found only in cases presenting simultaneous resistance to Thiacetazone. Resistance to Isoxyl produced by treatment with Isoxyl may be accompanied by Thiacetazone resistance. However, a crossed resistance to Ethionamide does not succeed apparently.

The importance of this statement for clinical and ambulant chemotherapy is discussed.

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Authors and Affiliations

  1. Klinik für Tuberkulose und Lungenkrankheiten des Magistrats von Groß-Berlin, Abt. Gesundheits- und Sozialwesen, Hellmuth-Ulrici-Klinik, Kr. Oranienburg, Sommerfeld

    H. Eule & E. Werner

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  1. H. Eule
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  2. E. Werner
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Eule, H., Werner, E. Die Resistenz des Mycobacterium tuberculosis gegen Ethionamid, Thiosemicarbazon und Isoxyl und ihre Beziehungen zueinander. Beitr. Klin. Tuberk. 134, 247–258 (1967). https://doi.org/10.1007/BF02098519

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