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Dinatrium cromoglicium beim belastungs- und hyperventilationsinduzierten Asthma

Sodium cromoglycate in exercise- and hyperventilation induced asthma

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Abstract

The effect of physical exertion and intentional hyperventilation on the bronchial motoricity, with and without previous inhalation of SCG, was investigated in 10 patients with chronic bronchial asthma and in 10 persons with normal lungs. Bronchoconstriction induced by exertion and hyperventilation was significantly reduced in the asthmatics after previous inhalation of SCG, while no measurable constriction at all could be found in the persons with normal lungs after the same procedure.

The possible sites of action of SCG, on the reflectory mechanisms which lead to a change in the bronchotonus, are discussed.

Zusammenfassung

Bei 10 Patienten mit chronischem Asthma bronchiale und bei 10 lungengesunden Personen wurde die Wirkung von körperlicher Belastung und willkürlicher Hyperventilation auf die Bronchomotorik mit und ohne Dinatrium cromoglicicum untersucht. Die nach Belastung und nach Hyperventilation auftretende Bronchokonstriktion war unter Dinatrium-cromoglicicum-Medikation bei den Lungengesunden nicht mehr nachweisbar, bei den Asthmatikern signifikant geringer ausgeprägt. Die möglichen Angriffspunkte von Dinatrium cromoglicicum in den reflektorischen Mechanismen, die zur Veränderung des Bronchotonus führen, werden erörtert.

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Authors and Affiliations

  1. Sektion Pulmonologie des Zentrums für Innere Medizin und Kinderheilkunde der Universität Ulm, Germany

    N. Konietzko, G. Overrath, H. Schlehe, K. H. Rühle & H. Matthys

Authors
  1. N. Konietzko
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  2. G. Overrath
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  3. H. Schlehe
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  4. K. H. Rühle
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  5. H. Matthys
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Additional information

Firmenbezeichnung: INTAL®.

Referat beim Intal-Symposium im Rahmen des 4. Colloquiums der Bad Reichenhaller Forschungsanstalt für Krankheiten der Atmungsorgane. Bad Reichenhall 18. 6. 1971.

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Konietzko, N., Overrath, G., Schlehe, H. et al. Dinatrium cromoglicium beim belastungs- und hyperventilationsinduzierten Asthma. Pneumonologie 146, 210–215 (1971). https://doi.org/10.1007/BF02097379

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  • DOI: https://doi.org/10.1007/BF02097379

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